Antitumor Alkaloids in Tibetan Corydalis: Chemical Diversity and Pharmacological Insights

25 June 2025 : Review article

Linguo Cao^{ABE 1}, Lijun Liu^{C 2}, Yanyan Wang^{D 1}, Jiaqing Liu^{E 1}, Zuowu Xi^{EFG 3*}

DOI: 10.12659/MSM.947268

Med Sci Monit 2025; 31:e947268

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Introduction Phytochemical Research Pharmacologically Guided Q-Marker Discovery: From Compound Identification to Mechanistic Elucidation Chemotaxonomic Profiling: From Species Differentiation to Geo-Authenticity Assessment Analytical Technology Revolution: From Single-Component Quantification to Multi-Omics Integration Tradition Meets Innovation: Processing and Compatibility-Driven Q-Marker Modulation Clinical Applications Cell Cycle Arrest Induction of Tumor Cell Apoptosis Regulation of the MAPK Signaling Pathway Suppression of Tumor Angiogenesis Conclusions Future Directions References

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Table 2 Overview of medicinal Corydalis species: Distribution, medicinal parts, included standards, and identification methods.

No.	Distribution area	Medicinal part	Included standards	Identification items
1	Qinghai, Tibet	Whole plant	Standards of Tibetan Medicine (1979), Ministry-issued Standards – Tibetan Medicine	Macroscopic and Microscopic Identification
2	Sichuan, Tibet	Whole plant	Sichuan Medicinal Material Standards	Macroscopic and Powder Identification
3	Qinghai, Sichuan, Gansu	Whole plant	Standards for Chinese Medicinal Materials of Sichuan Province (2010), Standards for Tibetan Medicinal Materials of Qinghai Province (2019)	Macroscopic, Powder, and Physicochemical Identification
4	Qinghai, Sichuan	Whole plant	Standards for Tibetan Medicinal Materials of Sichuan Province (2020)	Macroscopic, Microscopic, and Thin-layer Chromatography Identification
5	Tibet, Qinghai	Whole plant	Standards of Tibetan Medicine, etc.	Macroscopic and Microscopic Identification
6	Sichuan, Tibet	Whole plant	Standards for Tibetan Medicinal Materials of Sichuan Province (2020); Standards of Tibetan Medicine, etc.	Macroscopic and Microscopic Identification
7	Widely distributed nationwide	Whole plant	Chinese Pharmacopoeia 2020	Macroscopic, Microscopic, and Thin-layer Chromatography Identification
8	Sichuan, Yunnan	Tuber	Chinese Pharmacopoeia 2020	Macroscopic, Microscopic, and Thin-layer Chromatography Identification

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