22 March 2025 : Database Analysis
Utility of Central Venous Oxygen Saturation Gradient in Predicting Mortality in Dialysis with Catheter Access
Hung-Chieh Wu ABCEG 1,2*, Wei-Jie Wang BDF 3DOI: 10.12659/MSM.947298
Med Sci Monit 2025; 31:e947298
Table 1 Baseline characteristics of study population.
| Parameters | All participantsN=144 | SurvivorsN=112 | Non-survivorsN=32 | P value |
|---|---|---|---|---|
| Age (year) | 66.7±14.2 | 65.5±14.3 | 71.2±12.9 | 0.045* |
| Men (%) | 64 (44.4) | 48 (42.5) | 16 (51.6) | 0.417 |
| BMI (Kg/m) | 25.8±2.9 | 25.9±2.8 | 25.4±3.4 | 0.402 |
| Vintage of dialysis (yr) | 4.8±2.5 | 4.9±2.5 | 4.4±2.1 | 0.289 |
| Length of follow-up (months) | 14.8 (11.6, 19) | 14.8 (11.6, 18.9) | 12.4 (11.1, 18.0) | 0.861 |
| Comorbidities | ||||
| DM (n) | 76 | 60 | 16 | 1.000 |
| Hypertension (n) | 94 | 82 | 12 | 0.120 |
| CHF (n) | 30 | 24 | 6 | 1.000 |
| Laboratory data | ||||
| Albumin (g/L) | 37.7±3.1 | 37.9±2.9 | 36.8±3.5 | 0.088 |
| Total protein (g/L) | 67.4±6.2 | 67.6±5.9 | 66.8±7.2 | 0.510 |
| Creatinine (mmol/L) | 0.83±0.21 | 0.85±0.23 | 0.74±0.24 | 0.020* |
| Hemoglobin (g/L) | 100.9±11.2 | 100.6±11.7 | 101.8±9.3 | 0.595 |
| iPTH (ng/L) | 350 (177, 1626) | 360 (189, 1625) | 271 (110, 746) | 0.525 |
| Ferritin (nmol/L) | 1.04±0.98 | 0.99±0.83 | 1.23±1.58 | 0.305 |
| Mean ScvO2 (%) | 67.3±6.9 | 68.0±7.2 | 64.5±4.9 | 0.015* |
| Max ScvO2 (%) | 74.1±4.7 | 74.6±5.2 | 74.1±4.6 | 0.592 |
| Min ScvO2 (%) | 59.7±9.7 | 60.3±10.2 | 57.6±7.3 | 0.174 |
| Start ScvO2 (%) | 70.2±4.8 | 70.3±4.9 | 69.0±4.6 | 0.186 |
| End ScvO2 (%) | 61.7±11.5 | 62.2±12.0 | 59.8±8.9 | 0.291 |
| SD of ScvO2 | 2.4±1.3 | 2.1±1.1 | 3.4±1.4 | <0.001* |
| Average slope of ScvO2 (%/hr) | −0.02 (−0.89, 0.69) | 0.69 (0.36, 1.14) | −0.88 (−1.49, −0.38) | 0.001* |
| Dialysis information | ||||
| Mean pre-dialysis SBP (mmHg) | 139±19 | 138±19 | 143±19 | 0.278 |
| Mean UFV (liter) | 2.4±0.8 | 2.4±0.8 | 2.4±0.8 | 0.956 |
| Mean UFR (ml/Kg/hr) | 10.4±2.6 | 10.4±2.7 | 10.4±2.2 | 0.924 |
| Treatment time (hrs) | 3.9 (3.5, 4.0) | 3.9 (3.5, 4.0) | 3.5 (3.3, 3.9) | 0.001* |
| Proportion of IDH (%) | 16±17 | 12±13 | 31±22 | <0.001* |
| Equilibrated Kt/Vurea | 1.67±0.29 | 1.67±0.29 | 1.63±0.29 | 0.490 |
| Average preHD weight (Kg) | 63.3±13.3 | 63.2±14.2 | 63.7±9.6 | 0.865 |
| Average ABV change (%) | −16.0 (−12.0, −18.0) | −16.0 (−14.0, −18.0) | −14.0 (−7.3, −26.7) | 0.515 |
| Average ABV slope (%/h) | −3.9 (−3.2, −5.1) | −3.9 (−3.2, −5.1) | −3.9 (−3.3, −5.1) | 0.861 |
| Average RBV slope (%/h) | −3.1 (−2.0, −4.0) | −3.1 (−2.0, −4.0) | −3.0 (−2.1, −4.0) | 0.417 |
| Data were percentage, mean±standard deviation, median (interquartile range (IQR)). * P BMI – body mass index; DM – diabetes mellitus; CHF – congestive heart failure; ScvO2 – central venous oxygen saturation; iPTH – intact parathyroid hormone; IDH – intradialytic hypotension; UFV – ultrafiltration volume; UFR – ultrafiltration rate; SD – standard deviation; ABV – absolute blood volume; RBV – relative blood volume. | ||||