Utility of Central Venous Oxygen Saturation Gradient in Predicting Mortality in Dialysis with Catheter Access

Hung-Chieh Wu; Wei-Jie Wang

doi:10.12659/MSM.947298

22 March 2025 : Database Analysis

Utility of Central Venous Oxygen Saturation Gradient in Predicting Mortality in Dialysis with Catheter Access

Hung-Chieh Wu^{ABCEG 1,2*}, Wei-Jie Wang^{BDF 3}

DOI: 10.12659/MSM.947298

Med Sci Monit 2025; 31:e947298

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Table 2 Univariate logistic regression and final model including fractionally transformed absolute blood volume(ABV) and interaction identified significant.

Parameter	β coefficient	SE	OR (95% CI)	p value
Univariate analysis
Age	0.032	0.016	1.032 (1.001–1.065)	0.048^*
Female	−0.368	0.407	0.692 (0.312–1.536)	0.366
BMI	−0.059	0.070	0.943 (0.822–1.281)	0.400
Dialysis vintage	−0.093	0.037	0.912 (0.769–1.081)	0.287
DM	−0.001	0.418	0.990 (0.442–2.221)	0.981
preHD SBP	0.014	0.013	1.014 (0.989–1.040)	0.276
CHF	−0.117	0.509	0.890 (0.328–2.416)	0.819
Ultrafiltration rate	−0.081	0.079	0.993 (0.851–1.158)	0.924
Kt/Vurea	−0.532	0.764	0.587 (0.131–2.026)	0.486
Albumin	−1.085	0.644	0.338 (0.096–1.194)	0.092
Total protein	−0.071	0.034	0.932 (0.871–0.996)	0.039^*
Creatinine	−0.192	0.084	0.825 (0.700–0.973)	0.022^*
Hemoglobin	0.096	0.179	1.100 (0.775–1.562)	0.593
Ferritin	0.192	0.193	1.212 (0.831–1.768)	0.231
iPTH	0.001	0.001	1.001 (1.000–1.001)	0.186
ABV slope	0.139	0.134	1.149 (0.885–1.493)	0.297
RBV slope	−0.079	0.126	0.924 (0.722–1.182)	0.530
(ABV-mean ABV)	−0.012	0.031	0.989 (0.930–1.051)	0.711
(ABV-meanABV)	0.013	0.004	1.013 (1.006–1.020)	0.001^*
(UFR-meanUFR)	0.081	0.079	1.085 (0.928–1.268)	0.305
(UFR-meanUFR)	−0.014	0.024	0.986 (0.941–1.034)	0.566
Mean ScvO2	−0.032	0.040	0.876 (0.810–0.948)	0.001^*
Final model
(ABV-mean ABV)	1.389	0.700	4.010 (1.071–15.520)	0.049^*
(ABV-mean ABV)	−0.150	0.060	0.860 (0.75–0.999)	0.047^*
(ABV-mean ABV)×Mean ScvO2	0.002	0.001	1.001 (1.000–1.004)	0.047^*
^* P SE – standard error; OR – odds ratio; BMI – body mass index; UFR – ultrafiltration rate; DM – diabetes mellitus; CHF – congestive heart failure; Kt/Vurea – dialysis adequacy; iPTH – intact parathyroid hormone; ABV – absolute blood volume; RBV – relative blood volume, ScvO2 – central vein oxygen saturation; (ABV-mean ABV) – centered ABV; (ABV-mean ABV) – squared term of centered ABV; (ABV-mean ABV)×Mean ScvO2 – interaction term between squared term of centered ABV and mean ScvO2.

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Utility of Central Venous Oxygen Saturation Gradient in Predicting Mortality in Dialysis with Catheter Access

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