Evaluation of Inflammatory Biomarkers in Parotid Tumors

17 August 2025 : Clinical Research

Aykut Ikinciogullari

^{ABCDEF 1*}, Burak Hazir

^{ABCDEF 1}, Erdem Aggunlu

^{ABCDEF 1}, Mustafa Colak

^{ACDEF 1}, Serdar Ensari

^{ADEF 1}, Haci Huseyin Dere

^{ADEF 1}

DOI: 10.12659/MSM.947334

Med Sci Monit 2025; 31:e947334

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Table 7 Diagnostic performance of NLR, PLR, SII, and SIRI in differentiating malignant tumors from benign tumors.

	AUC	Sensitivity	Specificity	PPV	NPV	Accuracy	Cut-Off
NLR	0.56	0.38	0.75	0.20	0.88	0.69	2.54
PLR	0.61	0.79	0.42	0.18	0.92	0.47	104
SII	0.58	0.62	0.52	0.17	0.89	0.53	518
SIRI	0.51	0.58	0.5	0.16	0.88	0.51	0.91
AUC – area under the curve; PPV – positive predictive value; NPV – negative predictive value; NLR – neutrophil to lymphocyte ratio; PLR – platelet-to-lymphocyte ratio; SII – systemic immune inflammation index; SIRI – systemic inflammation response index.

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