09 June 2025 : Clinical Research
Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study
Khalid J. Alzahrani ABCDEFG 1*DOI: 10.12659/MSM.947493
Med Sci Monit 2025; 31:e947493
Table 1 Computed average RMSD, RMSF, Rg, SASA, and HB values for wild-type, A307T, and N680S FSHR upon metformin binding.
| Parameters | Wild-type (Average±SD) | A307T (Average±SD) | N680S (Average±SD) |
|---|---|---|---|
| RMSD | 1.12±0.17 | 0.91±0.11 | 0.844±0.11 |
| RMSF | 0.41±0.36 | 0.38±0.29 | 0.39±0.33 |
| Rg | 4.06±0.08 | 4.07±0.06 | 4.13±0.07 |
| SASA | 362.39±2.56 | 362.12±2.36 | 364.27±2.21 |
| HB | 498.66±10.58 | 501.10±11.40 | 486.82±11.15 |
| SD – standard deviation. | |||