Impact of Depression, Fatigue, and Pain on Quality of Life in Slovak Multiple Sclerosis Patients

Wioletta Mikuľáková; Lucia Demjanovič Kendrová; Eleonóra Klímová; Štefánia Andraščiková; Miloslav Gajdoš

doi:10.12659/MSM.947630

26 April 2025 : Clinical Research

Impact of Depression, Fatigue, and Pain on Quality of Life in Slovak Multiple Sclerosis Patients

Wioletta Mikuľáková

^{ABCDEFG 1*}, Lucia Demjanovič Kendrová

^{BDEF 1}, Eleonóra Klímová^{BDEF 1}, Štefánia Andraščiková

^{EFG 2}, Miloslav Gajdoš

^{DEF 1}

DOI: 10.12659/MSM.947630

Med Sci Monit 2025; 31:e947630

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Table 3 Correlations of monitored predictors with PCS, MCS, and PHS SF-36 among multiple sclerosis patients.

Parameters	Physical component summary		Mental component summary		Perceived health status

	Mean±SD or r	Me or P	Mean±SD or r	Me or P	Mean±SD or r	Me or P

	−0.191	0.010	−0.036	0.748	−0.124	0.136

	0.023	0.203	0.117	0.101	0.053	0.118

Men	37.38±24.05	33.75	39.42±14.83	35.62	38.40±17.82	34.12
Women	40.29±20.25	38.75	46.40±19.24	42.32	43.35±17.87	42.68

	0.338		0.117	0.052	0.284

Elementary	20.43±10.62	20.62	34.45±10.20	35.50	27.44±10.40	20.06
High school	37.80±21.05	21.05	44.54±18.92	39.81	41.17±18.33	38.53
Higher education	48.48±17.77	43.43	49.40±18.72	49.97	48.94±15.36	48.60

	0.491		−0.200		−0.384

Without restrictions	60.03±22.92	58.43	54.88±17.00	57.12	57.46±18.47	57.08
With restrictions	50.79±19.17	45.62	50.30±19.73	52.75	50.55±17.93	45.75
Disability pension	33.32±15.82	33.75	42.35±18.36	38.00	37.84±15.14	35.50

	−0.327		−0.153	0.043	−0.217

0–4 years	55.41±27.16	47.50	51.36±19.66	50.55	53.38±22.47	48.05
5–8 years	47.34±15.63	50.62	45.23±13.51	42.32	46.28±12.08	45.87
9 years and more	34.08±16.26	33.75	43.67±19.02	39.25	38.88±15.72	35.50

	−0.384		−0.097	0.052	−0.278

RR MS	44.68±19.46	42.50	45.58±18.67	40.25	45.13±17.66	42.43
PR MS	34.73±14.59	31.43	43.01±18.00	37.78	38.87±13.11	37.61
SR MS	25.90±14.33	24.50	41.16±20.31	33.25	33.53±15.54	32.18

	−0.604		−0.238		−0.476

EDSS 1–3.5	52.63±22.53	48.12	49.07±18.24	49.75	50.85±18.90	46.93
EDSS 4–6	37.16±14.13	35.62	46.56±17.90	41.25	41.86±21.50	39.68
EDSS 6.5–8	20.67±12.17	17.81	35.14±19.03	29.25	27.91±13.48	23.96

	−0.439		0.239		0.388

No	30.60±13.46	30.31	40.43±17.44	35.75	35.51±13.51	34.12
Yes	50.04±22.63	46.25	50.86±18.82	50.90	50.45±18.90	49.09

	−0.610		−0.606		−0.678

MFIS 0–38	57.10±21.19	50.62	61.28±15.69	65.87	59.19±15.86	59.62
MFIS 39–84	32.05±15.17	31.87	38.20±15.39	35.00	35.12±13.10	33.25

	−0.594		−0.605		−0.662

SDS 25–49	49.60±21.44	45.62	54.31±17.58	56.75	51.96±17.58	49.75
SDS 50–59	31.88±14.58	32.81	39.28±13.25	37.87	35.58±11.94	34.56
SDS 60–70	24.27±11.08	24.37	27.33±8.36	28.75	26.44±9.28	28.06

	−0.519		−0.507		−0.580

PES 6–14	53.42±24.54	48.12	56.39±18.72	62.18	54.91±18.69	54.06
PES 15–22	35.63±15.92	35.93	42.58±16.14	38.53	39.12±14.22	39.15
PES 23–30	28.30±14.95	27.18	34.23±15.89	31.75	31.38±12.50	31.40

	0.369		0.403		0.433

MSSS 68–100	48.49±22.67	45.00	68.95±13.42	72.00	50.96±18.74	49.37
MSSS 36–67	33.47±14.87	33.75	45.57±15.81	41.37	36.47±12.62	34.12
MSSS 18–35	25.15±13.91	21.25	33.80±15.45	29.43	28.41±12.82	27.59
SF-36 – Short Form 36 Health Subject Questionnaire; PHS – perceived health status; PCS – physical component summary; MCS – mental component summary; MFIS – Modified Fatigue Impact Scale (0: min. fatigue, 84: max. fatigue); SDS – Zung’s Self-Rating Depression Scale (less than 50: no depression, more than 70 severe depression); PES – Pain Effect Scale (6: min. pain, 30: max. pain); MSSS – Modified Social Support Survey (0: min. support, 100: max. support); RR MS – relapsing-remitting MS; PR MS – primary progressive MS; SR MS – secondary progressive MS; SD – standard deviation; Me – median; Min. – minimum values; Max. – maximum values; r – Spearman correlation coefficients; – level of significance.

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Impact of Depression, Fatigue, and Pain on Quality of Life in Slovak Multiple Sclerosis Patients

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