26 April 2025 : Clinical Research
Impact of Depression, Fatigue, and Pain on Quality of Life in Slovak Multiple Sclerosis Patients
Wioletta Mikuľáková
ABCDEFG 1*, Lucia Demjanovič Kendrová BDEF 1, Eleonóra Klímová BDEF 1, Štefánia Andraščiková EFG 2, Miloslav Gajdoš DEF 1
DOI: 10.12659/MSM.947630
Med Sci Monit 2025; 31:e947630
Table 4 Multiple regression model for PCS, MCS, and PHS SF-36 among multiple sclerosis patients.
| Variables | Physical component summary | Mental component summary | Perceived health status | ||||||
|---|---|---|---|---|---|---|---|---|---|
| β (SE) | t | P | β (SE) | t | P | β (SE) | t | P | |
| Constant | 90.718 | 66.567 | 76.876 | ||||||
| Age | 0.113 (0.108) | 1.047 | 0.297 | 0.767 (0.120) | 0.637 | 0.525 | 0.107 (0.091) | 1.178 | 0.241 |
| Gender | −2.172 (3.033) | −0.716 | 0.475 | 7.214 (3.377) | 2.136 | 2.730 (2.565) | 1.064 | 0.289 | |
| Education | 2.755 (2.217) | 1.243 | 0.216 | 0.765 (2.469) | 0.310 | 0.757 | 1.664 (1.875) | 0.888 | 0.376 |
| Work capacity | −3.545 (1.837) | −1.929 | 0.056 | −1.967 (2.045) | −0.962 | 0.338 | −2.667 (1.554) | −1.717 | 0.088 |
| Immuno-modulatory therapy | 4.401 (2.474) | 1.779 | 0.077 | 2.905 (2.754) | 1.055 | 0.293 | 3.939 (2.092) | 1.883 | 0.062 |
| Disease duration | −2.799 (1.411) | −1.982 | 0.978 (1.571) | 0.622 | 0.535 | −1.014 (1.194) | −0.849 | 0.397 | |
| Course of disease | −2.434 (1.490) | −1.634 | 0.104 | 1.208 (1.659) | 0.729 | 0.467 | −0.524 (1.260) | −0.416 | 0.678 |
| EDSS | −1.654 (0.944) | −1.725 | 0.082 | 1.588 (1.051) | 1.511 | 0.133 | −0.059 (0.798) | −0.074 | 0.940 |
| MFIS | −0.246 (0.077) | −3.162 | −0.361 (0.086) | −4.178 | −0.303 (0.065) | −4.620 | |||
| PES | −0.619 (0.203) | −2.989 | −0.663 (0.230) | −2.875 | −0.673 (0.175) | −3.842 | |||
| SDS | −0.423 (0.132) | −3.202 | −0.548 (0.147) | −3.722 | −0.464 (0.111) | −4.150 | |||
| MSSS | 0.068 (0.044) | 1.530 | 0.128 | 0.151 (0.049) | 3.055 | 0.112 (0.037) | 2.990 | ||
| Model characteristic | R=0.68, ΔR=0.65, F=22.01, <0.0001 | R=0.57, ΔR=0.53, F=13.49, <0.0001 | R=0.70, ΔR=0.67, F=24.42, <0.0001 | ||||||
| SF-36 – Short Form 36 Health Subject Questionnaire; PHS – perceived health status; PCS – physical component summary; MCS – mental component summary; EDSS – Expanded Disability Status Scale; MFIS – Modified Fatigue Impact Scale; PES – Pain Effect Scale; SDS – Zung’s Self – Rating Depression Scale; MSSS – Modified Social Support Survey; Me – median, Min. – minimum values; Max. – maximum values; β – Beta – coefficients; SE – standard error; R - coefficient of determination; ΔR – squared coefficient of determination; F – test statistic of F test; t – test statistics; – level of significance. | |||||||||