16 September 2025 : Clinical Research
Thoracic Radiation on Survival in Patients with Advanced Small Cell Lung Cancer Treated with Chemoimmunotherapy
Yunbin Gao ABG 1,2, Xuyu Zhang BCE 1, Dawei Zhao BEF 1, Jifeng Sun BDE 1, Lixia Zhang BCEF 3, Song Guan BDEF 3, Lujun Zhao AE 3*DOI: 10.12659/MSM.947713
Med Sci Monit 2025; 31:e947713
Table 2 Results of the univariate analysis of patient features and survival.
| Characteristic | Overall survival | Progression-free survival | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Group | ||||||
| Non-TRT | 1.00 | 1.00 | ||||
| TRT | 0.52 | 0.32–0.83 | 0.007 | 0.48 | 0.33–0.71 | <0.001 |
| Sex | ||||||
| Female | 1.00 | 1.00 | ||||
| Male | 1.03 | 0.61–1.73 | 0.907 | 1.36 | 0.88–2.1 | 0.168 |
| Age | ||||||
| <65 | 1.00 | 1.00 | ||||
| ≥65 | 1.96 | 1.26–3.06 | 0.003 | 1.69 | 1.17–2.45 | 0.005 |
| ECOG | ||||||
| 1 | 1.00 | 1.00 | ||||
| 0 | 0.62 | 0.23–1.72 | 0.362 | 0.44 | 0.16–1.21 | 0.112 |
| 2 | 0.92 | 0.37–2.28 | 0.853 | 0.94 | 0.47–1.86 | 0.854 |
| T | ||||||
| T1 | 1.00 | 1.00 | ||||
| T2 | 2.38 | 0.91–6.21 | 0.076 | 1.40 | 0.7–2.8 | 0.341 |
| T3 | 2.19 | 0.82–5.85 | 0.117 | 1.12 | 0.54–2.3 | 0.766 |
| T4 | 1.96 | 0.75–5.13 | 0.171 | 1.16 | 0.58–2.33 | 0.680 |
| N | ||||||
| N1 | 1.00 | 1.00 | ||||
| N2 | 1.07 | 0.42–2.74 | 0.880 | 1.27 | 0.58–2.79 | 0.550 |
| N3 | 0.80 | 0.31–2.04 | 0.636 | 0.84 | 0.38–1.86 | 0.673 |
| Total stage | ||||||
| III | 1.00 | 1.00 | ||||
| IVA | 3.45 | 0.47–25.5 | 0.225 | 3.96 | 0.96–6.44 | 0.058 |
| IVB | 5.98 | 0.83–43.33 | 0.077 | 5.91 | 1.45–4.13 | 0.013 |
| Oligometastases | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 0.67 | 0.41–1.08 | 0.100 | 0.67 | 0.45–0.99 | 0.043 |
| Brain metastases | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 1.42 | 0.84–2.38 | 0.186 | 1.11 | 0.71–1.74 | 0.639 |
| Bone metastases | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 1.62 | 1.03–2.56 | 0.038 | 1.63 | 1.13–2.37 | 0.010 |
| Liver metastases | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 1.83 | 1.15–2.91 | 0.011 | 1.57 | 1.06–2.33 | 0.026 |
| CI – confidence interval; HR – hazard ratio; TRT – thoracic radiation therapy; ECOG – Eastern Cooperative Oncology Group. | ||||||