Model Construction for Predicting Preoperative Microvascular Invasion of Hepatocellular Carcinoma by Gadoxetic Acid Disodium-Enhanced Magnetic Resonance Imaging Combined with Serology

01 July 2025 : Clinical Research

Siman Sheng^{ABCDEF 1}, Xu Fu^{ABCDEF 2}, Mengjie Li^{ABCDEF 1}, Wei Ye^{BCDE 3}, Xiaoyu Chen^{BCDEF 3}, Chuang Chen^{ABCDEFG 1*}

DOI: 10.12659/MSM.947809

Med Sci Monit 2025; 31:e947809

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Table 2 Logistic univariate and multivariate regression analysis of training group.

Characteristic	Single factor analysis			Multifactor analysis
Characteristic	OR	95% CI	P value	OR	95% CI	P value
Sex	0.600	0.206–1.750	0.350
Age	1.033	0.991–1.078	0.127
WBC	1.038	0.852–1.264	0.714
PLT	1.003	0.995–1.010	0.499
ALT	0.997	0.988–1.006	0.452
AST	1.002	0.991–1.014	0.686
TBil	0.959	0.902–1.020	0.188
AFP	1.002	1.000–1.005	0.026	1.002	1.000–1.005	0.052
ALP	0.998	0.990–1.007	0.730
PLR	0.995	0.988–1.002	0.180
NLR	0.824	0.673–1.010	0.062
CAR	26.971	5.568–30.568	0.004	35.312	3.064–43.293	0.029
HBsAg	1.097	0.441–2.728	0.842
Size	1.132	0.99–1.294	0.069
Tumor typing	2.403	0.934–6.178	0.069
Arterial phase
Peritumoral enhancement	2.867	0.868–9.465	0.084
Periarterial high signal ring	2.449	0.907–6.617	0.077
Hepatobiliary phase
Tumor signal	2.459	1.005–6.016	0.049	3.559	1.206–10.499	0.021
Peritumoral hypointensity	15.667	1.881–130.456	0.011	15.296	1.741–134.358	0.014
WBC – white blood cell; ALT – alanine aminotransferase; AST – aspartate aminotransferase; TBil – total bilirubin; AFP – alpha-fetoprotein; ALP – alkaline phosphatase; PLR – platelet to lymphocyte ratio; NLR – neutrophil to lymphocyte ratio; CAR – C-reactive protein to albumin ratio; HBsAg – hepatitis B virus surface antigen; OR – odds ratio; 95% CI – 95% confidence interval.

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