03 July 2025 : Review article
Advances in Research on Concentrated Growth Factor Applications for Androgenetic Alopecia Treatment: A Review
Di Zhou ABCDEF 1, Zhi-Wan Liu AF 1, Xiang Jie BCD 1, Xiaohai Zhu ADG 1*DOI: 10.12659/MSM.948054
Med Sci Monit 2025; 31:e948054
Table 1 Summary of common treatment methods for alopecia.
| Therapy | Adverse effects | Notes |
|---|---|---|
| Topical minoxidil | Irritant contact dermatitis, allergic reactions, hypertrichosis | During the initial usage period, it is possible to experience exacerbated symptoms of hair loss, and there may also be unintended hair growth in non-targeted areas |
| Oral minoxidil | Cardiac-related adverse effects, hypertrichosis, headaches, nausea, and vomiting | The consultation with a physician is recommended to carefully evaluate the potential adverse effects relative to the treatment benefits when contemplating the utilization of oral minoxidil |
| Topical finasteride | Scalp irritation, Contact dermatitis, Mood fluctuations | Although topical application reduces systemic exposure, it can still impact sexual function, leading to a decrease in libido or the development of erectile dysfunction |
| Oral finasteride | Sexual dysfunction, psychological effects, gynecomastia | Refraining from the use of oral finasteride is advised for female patients |
| Oral spironolactone | Electrolyte imbalance, dizziness and fatigue, hypotension | Refrain from usage in patients presenting with abnormal hepatic function, renal insufficiency, expectant mothers, and lactating women |
| Mesotherapy | Localized pain and discomfort, risk of infection, scar formation | The efficacy of mesotherapy can vary among individuals, and some may not achieve the anticipated outcomes in terms of hair growth results |
| Light therapy | Eye discomfort, crusting and rash, changes in hair color | High frequency of treatment |
| Hair transplant | Infection, pain, edema, hemorrhage, scarring, pruritus | The treatment entails a substantial cost and necessitates subsequent maintenance medication therapy |