03 July 2025 : Review article
Advances in Research on Concentrated Growth Factor Applications for Androgenetic Alopecia Treatment: A Review
Di Zhou ABCDEF 1, Zhi-Wan Liu AF 1, Xiang Jie BCD 1, Xiaohai Zhu ADG 1*DOI: 10.12659/MSM.948054
Med Sci Monit 2025; 31:e948054
Table 2 Comparative analysis of CGF, traditional treatments, PRP, and PRF.
| Indicator | PRP | PRF | CGF | Traditional treatment |
|---|---|---|---|---|
| Growth Factor Release | Rapid (24–72 hours) | Slow (7–14 days) | Sustained (over 21–28 days) | No direct regenerative promotion effect |
| Fibrin Structure | Loose and easily decomposable | Three-dimensional network, medium stability | Dense multi-layer, most stable structure | N/A |
| Stem Cell Content | Extremely low or none | Small amount (CD34) | High concentration (CD34 stem cells) | N/A |
| Anti-inflammatory Effect | Weak (few leukocytes) | Strong (moderate leukocytes) | Strongest (high leukocyte conc.) | Drug-dependent (eg, antibiotics) |
| Operational Simplicity | Requires anticoagulants, complex steps | Additive-free, simple procedure | Complex centrifugation protocol | Standardized protocols |