02 February 2025 : Review article
A Review of CAR T Cells and Adoptive T-Cell Therapies in Lymphoid and Solid Organ Malignancies
Dinah V. Parums1CDEF*DOI: 10.12659/MSM.948125
Med Sci Monit 2025; 31:e948125
Table 1 Current status of ten commercially available and approved chimeric antigen receptor (CAR) T-cell therapies (2017–2024) [2,4].
Generic name (brand name) | Target | Approved treatment | Patient population |
---|---|---|---|
CD19 | B-cell NHLB-cell ALL | Adults with relapsed or refractory B-cell NHLChildren/young adults with relapsed or refractory B-cell ALL | |
CD19 | MCLB-cell ALL | Adults with relapsed or refractory MCLAdults with relapsed or refractory B-cell ALL | |
CD19 | B-cell NHLFollicular lymphoma | Adults with relapsed or refractory B-cell NHLAdults with relapsed or refractory follicular lymphoma | |
CD19 | B-cell NHL | Adults with relapsed or refractory B-cell NHL | |
BCMA | Multiple myeloma | Adults with relapsed or refractory multiple myeloma | |
BCMA | Multiple myeloma | Adults with relapsed or refractory multiple myeloma | |
CD19 | Large B-cell lymphoma (LBCL) | Adults with relapsed or refractory LBCL | |
CD19 | B-cell ALL | Adults with relapsed or refractory B-cell ALL | |
CD19 | B-cell NHL and B-cell ALL | Adults with relapsed or refractory B-cell NHL and ALL | |
CD19 | B-cell NHL | Adults with relapsed or refractory B-cell NHL | |
ALL – acute lymphoblastic lymphoma; BCMA – B-cell maturation antigen; LBCL – large B-cell lymphoma; NHL – Non-Hodgkin lymphoma; MCL – mantle cell lymphoma. |