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02 February 2025 : Review article  

A Review of CAR T Cells and Adoptive T-Cell Therapies in Lymphoid and Solid Organ Malignancies

Dinah V. Parums1CDEF*

DOI: 10.12659/MSM.948125

Med Sci Monit 2025; 31:e948125

Table 1 Current status of ten commercially available and approved chimeric antigen receptor (CAR) T-cell therapies (2017–2024) [2,4].

Generic name (brand name)TargetApproved treatmentPatient population
CD19B-cell NHLB-cell ALLAdults with relapsed or refractory B-cell NHLChildren/young adults with relapsed or refractory B-cell ALL
CD19MCLB-cell ALLAdults with relapsed or refractory MCLAdults with relapsed or refractory B-cell ALL
CD19B-cell NHLFollicular lymphomaAdults with relapsed or refractory B-cell NHLAdults with relapsed or refractory follicular lymphoma
CD19B-cell NHLAdults with relapsed or refractory B-cell NHL
BCMAMultiple myelomaAdults with relapsed or refractory multiple myeloma
BCMAMultiple myelomaAdults with relapsed or refractory multiple myeloma
CD19Large B-cell lymphoma (LBCL)Adults with relapsed or refractory LBCL
CD19B-cell ALLAdults with relapsed or refractory B-cell ALL
CD19B-cell NHL and B-cell ALLAdults with relapsed or refractory B-cell NHL and ALL
CD19B-cell NHLAdults with relapsed or refractory B-cell NHL
ALL – acute lymphoblastic lymphoma; BCMA – B-cell maturation antigen; LBCL – large B-cell lymphoma; NHL – Non-Hodgkin lymphoma; MCL – mantle cell lymphoma.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750