15 August 2025 : Clinical Research
Comparative Analysis of Hemodiafiltration Methods: Efficacy and Safety in Maintenance Hemodialysis
Zhuojia Xu ABCDEFG 1*, Dongdong Wang ABCDEF 1, Kai Wang BCDE 1, Guoyu Liang BCDE 1DOI: 10.12659/MSM.948227
Med Sci Monit 2025; 31:e948227
Table 2 Primary outcome analysis: urea reduction ratio and serum reduction ratios according the 5 hemodiafiltration modalities.
| Variable (unit) | T1 | T2 | T3 | T4 | T5 |
|---|---|---|---|---|---|
| Pre urea (mmol/L) | 23.75±5.19 | 23.15±4.62 | 24.26±6.41 | 23.35±5.24 | 21.79±5.4 |
| Post urea (mmol/L) | 7.54±2.38 | 6.93±2.31 | 6.89±2.54 | 7.22±2.18 | 6.79±2.44 |
| URR (%) | 67.81±9.38 | 71.15±6.01 | 71.5±7.52 | 70.38±8.08 | 68.23±11.8 |
| Pre β2-MG (mg/L) | 28.47±4.36 | 29.65±3.72 | 30.26±4.98 | 29.4±5.43 | 31.8±6.68 |
| Post β2-MG (mg/L) | 10.58±1.96 | 7.92±1.96 | 8.62±1.95 | 9.12±2.01 | 8.52±2.16 |
| Postcorr β2-MG (mg/L) | 8.676±1.58 | 6.44±1.58 | 7.11±1.61 | 7.52±1.71 | 7.08±1.93 |
| β2-MG RR (%) | 69.23±5.21b | 78.38±4.17a | 76.32±5.14a | 75.20±4.64a | 77.68±5.01a |
| Pre α1-MG (mg/L) | 237.2±35.54 | 242.7±33.89 | 246.4±34.39 | 243.5±35.28 | 233.7±33.93 |
| Post α1-MG (mg/L) | 266±48.98 | 261.8±53.77 | 263.6±48.14 | 276.7±65.94 | 257.3±56.85 |
| Postcorr α1-MG (mg/L) | 217.4±34.42 | 211.7±37.0 | 221.2±35.38 | 227.1±50.56 | 212.3±43.5 |
| α1-MG RR (%) | 8.23±6.11b | 13.06±6.00a | 10.50±5.72 | 8.21±10.01b | 10.81±8.40 |
| Data are expressed as mean±standard deviation. All analyses were conducted using the Kruskal-Wallis non-parametric test. a b c d e MG – macroglobulin; RR – reduction ratio; URR – urea reduction ratio. | |||||