11 June 2025 : Clinical Research
GFAP/UCH-L1 as a Biomarker for Rapid Assessment of Mild TBI in Emergency Departments
Rakesh Jalali
ABCDEFG 1,2*, Marcin Bałuch BCE 1,2, Joanna Malinowska BF 1,2, Jacek Zwiernik BF 3, Adam Kern BF 4, Jacek Bil BF 5, Jerzy Romaszko BF 6
DOI: 10.12659/MSM.948353
Med Sci Monit 2025; 31:e948353
Table 2 Sensitivity and specificity in age groups. Cut-off points were set at 35 pg/ml for glial fibrillary acid protein (GFAP) and 400 pg/ml for ubiquitin L1 C-terminal hydrolase (UCH-L1).
| Age group | Test | Sensitivity | Specificity |
|---|---|---|---|
| 18–40 years old | GFAP | 0% | 85.7% |
| UCH-L1 | 0% | 76.2% | |
| TBI | 0% | 66.7% | |
| 40–65 years old | GFAP | 100% | 45.9% |
| UCH-L1 | 100% | 75.7% | |
| TBI | 100% | 29.7% | |
| >65 years old | GFAP | 100% | 14.0% |
| UCH-L1 | 50% | 51.7% | |
| TBI | 100% | 12.1% |