16 August 2025 : Clinical Research
Challenges in Diagnosing and Treatment of Pediatric Necrotic Skin Conditions: A Retrospective Study
Wioletta Pasieczna
ABCDEF 1*, Natalia Zaj ABCDEF 1, Marika Jerzak ABCDEF 1, Karol P. Ruszel CDEF 2, Anna Bodajko-Grochowska ACDE 3, Ewelina Wawryk-Gawda DE 4, Violetta Opoka-Winiarska DE 4
DOI: 10.12659/MSM.948373
Med Sci Monit 2025; 31:e948373
Table 3 A summary of the main analyzed factors and their influence on hospital management and outcomes of children suffering from Stevens-Johnson syndrome and toxic epidermal necrolysis.
| Patient No. | Etiology | Time from exposure to first symptoms | Prodromal symptoms | Treatment | Complications | Outcome | Days of hospitalization | |
|---|---|---|---|---|---|---|---|---|
| 1 | Prokaryotic infection | 7 days | Present | Supportive + antibiotics + GCs* | None | Remission | 13 | |
| 2 | 3 days | Present | Supportive + antibiotics + GCs + IVIG* | None | Remission | 18 | ||
| 3 | 6 days | Present | Supportive + antibiotics + GCs* | None | Remission | 8 | ||
| 4 | 6 days | Present | Supportive + antibiotics + GCs* | None | Remission | 11 | ||
| 5 | – | Present | Supportive + antibiotics* | None | Remission | 8 | ||
| 6 | Medication | Oxcarbazepine | 2 days | Present | Supportive + antibiotics + GCs + IVIG* | None | Remission | 8 |
| 7 | Ibuprofen | 3 days | Present | Supportive + GCs* | None | Remission | 6 | |
| 8 | Ibuprofen | 4 days | Present | Supportive + antibiotics + GCs* | None | Remission | 12 | |
| 9 | Lamotrigine | 2 days | Absent | Supportive + antibiotics + GCs + cyclosporine + IVIG* | Headache | Progression followed by remission** | 2 | |
| 10 | Clarithromycin | 4 days | Present | Supportive + antibiotics + GCs* | None | Remission | 9 | |
| 11 | Paracetamol | – | Present | Supportive + antibiotics + GCs* | None | Remission | 8 | |
| 12 | Unknown triggering factor | Unknown | – | Absent | Supportive + antibiotics + GCs + IVIG* | Iatrogenic Cushing’s syndrome | Remission | 22 |
| 13 | Unknown | – | Absent | Supportive + antibiotics + GCs* | None | Remission | 8 | |
| * Lubricants, antibiotics, antiseptic dressings, artificial tears, pain treatment (paracetamol, lignocaine), water, and electrolytes; ** the patient was treated in the burn unit, then in the Intensive Care Unit with improvement. GCs – systemic glucocorticoids; IVIG – intravenous immunoglobulin. | ||||||||