27 June 2025 : Review article
A Comprehensive Bibliometric Analysis of Biomedical Research Waste: Current Situation, Development, and Trends
Lei Peng ABCDEF 1, Jinqian Li CDEF 2, Yan Chu DEF 1,3, Honghao Song DE 1, Kaiqiang Sun F 4,5, Jingchuan Sun F 4, Jianping Fan A 4*, Chen Yan AC 2, Hongbin Yuan AG 1DOI: 10.12659/MSM.948390
Med Sci Monit 2025; 31:e948390
Table 2 The top 10 most cited research papers.
| Order | First author | Source | Year | Citations | Average citation | Title | Keyword |
|---|---|---|---|---|---|---|---|
| 1 | Marcus R Munafò []28 | Nature Human Behaviour | 2017 | 1851 | 264.4 | A Manifesto for Reproducible | Statistical power; increasing value; reducing waste |
| 2 | Patrick Royston []48 | Statistics In Medicine | 2006 | 1722 | 95.7 | Dichotomizing Continuous Predictors in Multiple Regression: A Bad Idea | Continuous covariates; dichotomization; categorization |
| 3 | Iain Chalmers []8 | Lancet | 2009 | 1461 | 97.4 | Avoidable Waste in the Production and Reporting of Research Evidence | Trials |
| 4 | Kerry Dwan []49 | PLoS One | 2008 | 1233 | 77 | Systematic Review of the Empirical Evidence of Study Publication Bias | Randomized trials; clinical trials; follow-up |
| 5 | Christopher J Pannucci []50 | Plastic and Reconstructive Surgery | 2010 | 1171 | 83.6 | Identifying and Avoiding Bias in Research | Clinical trial registration; estrogen plus registration; estrogen heart disease |
| 6 | Isabelle Boutron []51 | Annals of Internal Medicine | 2017 | 916 | 130.9 | CONSORT Statement for Randomized Trials of Nonpharmacologic Treatments: A 2017 Update and a CONSORT Extension for Nonpharmacologic Trial Abstracts | Clinical trials; interventions; design |
| 7 | Paul Glasziou []52 | Lancet | 2014 | 893 | 89.3 | Reducing Waste from Incomplete or Unusable Reports of Biomedical Research | Research publication; research reports; reporting guidelines |
| 8 | Gordon H Guyatt []53 | Journal of Clinical Epidemiology | 2011 | 882 | 67.8 | GRADE Guidelines: 5. Rating the Quality of Evidence-Publication Bias | GRADE; quality of evidence; publication bias |
| 9 | Craig J Whittington []54 | Lancet | 2004 | 758 | 37.9 | Selective Serotonin Reuptake Inhibitors in Childhood Depression: Systematic Review of Published versus Unpublished Data | Pharmaceutical industry; major depression; controlled trial |
| 10 | Lon S Schneider []55 | American Journal of Geriatric Psychiatry | 2006 | 664 | 36.9 | Efficacy and Adverse Effects of Atypical Antipsychotics for Dementia: Meta-Analysis of Randomized, Placebo-Controlled Trials | Antipsychotic; meta-analysis; Alzheimer disease |