24 June 2025 : Clinical Research
Biomarker Discovery in Childhood Asthma: A Pilot Study of Serum Metabolite Analysis for IgE-Dependent Allergy
Natalia Rzetecka
ABCDEF 1,2, Jan Matysiak ABDEG 1, Szymon Plewa BCDE 1, Joanna Matysiak BDE 3, Paulina Sobkowiak BE 4, Irena Wojsyk-Banaszak BE 4, Anna Bręborowicz BE 4, Weronika Pierz E 5, Agnieszka Klupczyńska-Gabryszak ABCDEF 1*
DOI: 10.12659/MSM.948478
Med Sci Monit 2025; 31:e948478
Table 1 Characteristics of patients in the study and control group.
| Variable | Patients with asthma and IgE-dependent allergy (study group) | Patients without asthma and IgE-dependent allergy (control group) |
|---|---|---|
| No. of subjects | 13 | 10 |
| Age (years) | ||
| Median | 3.7 | 3.7 |
| Mean±SD | 3.8±0.8 | 3.3±1.5 |
| Range | 2.3–4.9 | 0.8–4.9 |
| Sex (%) | ||
| Male | 61.5 | 40 |
| Female | 38.5 | 60 |
| Respiratory tract infection in the last 3 months (%)a | 85 | 90 |
| Bronchial asthma in parents (%)a | 31 | 20 |
| Bronchial obstruction, shortness of breath, wheezing in the last 12 months (%)a | 92 | 40 |
| Coughing or wheezing after exercise (%)a | 31 | 20 |
| Chronic rhinitis (%)a | 69 | 60 |
| Atopic dermatitis (%)a | 23 | 20 |
| Bronchial asthma (%) | 54 | 0 |
| Urticaria (%)a | 8 | 0 |
| Total IgE (kU/I) | ||
| Mean | 322.71 | 10.40 |
| Range | 5.1–1071 | 0.7–38.7 |
| Allergy | 100 | 0 |
| Allergy classes based on IgE concentration (%) | ||
| Class 2 | 0 | |
| Class 3 | 38.5 | |
| Class 4 | 30.8 | |
| Class 5 | 15.4 | |
| Class 6 | 15.4 | |
| Most common allergy (%) | ||
| Dog epithelia | 23.1 | |
| 30.8 | ||
| 15.4 | ||
| Apple | 15.4 | |
| Birch pollen | 15.4 | |
| Cat epithelia | 7.7 | |
| Cacao (chocolate) | 7.7 | |
| a Clinical data based on a questionnaire (completed by parents); b Asthma was diagnosed before participation in the study. | ||