24 June 2025 : Clinical Research
Biomarker Discovery in Childhood Asthma: A Pilot Study of Serum Metabolite Analysis for IgE-Dependent Allergy
Natalia Rzetecka
ABCDEF 1,2, Jan Matysiak ABDEG 1, Szymon Plewa BCDE 1, Joanna Matysiak BDE 3, Paulina Sobkowiak BE 4, Irena Wojsyk-Banaszak BE 4, Anna Bręborowicz BE 4, Weronika Pierz E 5, Agnieszka Klupczyńska-Gabryszak ABCDEF 1*
DOI: 10.12659/MSM.948478
Med Sci Monit 2025; 31:e948478
Table 7 Results from receiver operating characteristic (ROC) curve analysis of statistical significance metabolites between the study and control group.
| Metabolites abbreviations | AUCc | −95% CId | +95% CI | Cut-off point | Sensitivity% | Specificity% | Direction of diagnostic variable | P value |
|---|---|---|---|---|---|---|---|---|
| Serotonin synthesis | 0.80 | 0.616 | 0.999 | 0.013 | 61.5 | 100.0 | Destimulant | 0.01 |
| PC 40:4a | 0.80 | 0.599 | 1 | 2.75 | 76.9 | 90.0 | Stimulant | 0.01 |
| PC 36:0 | 0.73 | 0.496 | 0.966 | 1.55 | 92.3 | 60.0 | Destimulant | 0.06 |
| SM 44:2b | 0.73 | 0.502 | 0.959 | 0.45 | 92.3 | 60.0 | Destimulant | 0.06 |
| PC 38:0 | 0.73 | 0.512 | 0.950 | 3.04 | 84.6 | 60.0 | Destimulant | 0.06 |
| PC 28:1 | 0.69 | 0.441 | 0.943 | 2.53 | 92.3 | 60.0 | Destimulant | 0.12 |
| SM 35:1 | 0.70 | 0.458 | 0.949 | 3.17 | 100.0 | 50.0 | Destimulant | 0.10 |
| Serotonin synthesis and PC 40:4 | 0.89 | 0.751 | 1 | 0.67 | 76.9 | 100.0 | – | 0.001 |
| a Phosphatidylcholine; b sphingomyelin; a area under the curve; d confidence interval. | ||||||||