Neurofilament Light Chain and Disability Measures as Predictors of Cognitive Decline in Early Multiple Sclerosis

25 July 2025 : Clinical Research

Vera Taluntiene^{ABCDEF 1*}, Natasa Giedraitiene^{ADE 1}, Rasa Kizlaitiene^{AE 1}, Mantas Vaisvilas^{DE 1}, Gintaras Kaubrys

^{ACDE 1}

DOI: 10.12659/MSM.948757

Med Sci Monit 2025; 31:e948757

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Table 3 Linear regression models predicting BICAMS battery test scores.

Dependent variable	Regression models	R2	P (R2)
SDMT	50.99-0.51 × +1.14 × +3.23 × sex −1.40 ×	0.393	<0.001
	67.82-0.37 × +1.14 × +1.33 × sex −1.01 ×	0.490	<0.001
	65.86-0.36 × +0.69 × education +4.86 × sex −3.89 ×	0.478	<0.001
BVMT-R	16.75-0.06 × age +0.93 × −2.16 × sex −0.07 × EDSS −0.06 ×	0.193	<0.001
	19.71-0.03 × age +0.97 × −2.49 × sex −0.19 × NHPT −0.05 ×	0.211	0.001
	18.97+0.4 x age +0.89 × −2.30 × sex −1.43 × −0.002 × sNfL	0.147	0.006
CVLT-II	60.35-0.26 × +0.52 × education +7.15 × −0.47 × NHPT	0.235	<0.001
BVMT-R – Brief Visuospatial Memory Test-Revised; CSF – cerebrospinal fluid; CVLT-II – California Verbal Learning Test II; EDSS – Expanded Disability Status Scale; NfL – neurofilament light chain; NHPT – Nine-Hole Peg Test; SDMT – Symbol Digit Modalities Test; T25FWT – Timed 25-Foot Walk Test; R – proportion of variance in the dependent variable that can be explained by the independent variables. font indicates significant independent variables

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