29 October 2025 : Clinical Research
Diagnostic Value of Acoustic Analysis and Inflammation Markers in Pediatric Vocal Fold Nodules
Saime Güzelsoy Sagiroglu
ABCDEFG 1*
DOI: 10.12659/MSM.948789
Med Sci Monit 2025; 31:e948789
Table 2 Evaluation of diagnostic test performances of F0 mean, F0 min, F0 max, SD, Jitter, Shimmer, NHR, MPT, and pVHI variables using ROC analysis.
| Sensitivity | Specificity | Cut-Off | AUC (95% CI) | p | |
|---|---|---|---|---|---|
| F0 mean | 0.400 | 0.867 | 275.48 | 0.617 (0.472–0.762) | 0.121 |
| F0 min | 0.900 | 0.333 | 139.12 | 0.554 (0.406–0.702) | 0.469 |
| F0 max | 0.667 | 0.667 | 265.04 | 0.681 (0.545–0.818) | * |
| SD | 0.667 | 0.800 | 2.87 | 0.763 (0.641–0.885) | * |
| Jitter | 0.767 | 0.833 | 0.45 | 0.817 (0.708–0.926) | * |
| Shimmer | 0.967 | 0.733 | 1.835 | 0.907 (0.836–0.977) | * |
| Mean NHR | 0.800 | 0.867 | 0.0071 | 0.864 (0.770–0.959) | * |
| MPT | 0.733 | 0.663 | 8.79 | 0.712 (0.581–0.842) | * |
| VHI 10 | 0.733 | 0.800 | 9.950 | 0.808 (0.699–0.917) | * |
| ROC curve; a: 0.05; AUC – area of the under curve; * the relevant biomarker provided a statistically significant distinction between the case and control groups. | |||||