22 August 2025 : Review article
A Review of Modulation of Gut Microbiota to Mitigate Gestational Diabetes: Implications for Maternal and Child Health
Olimpia Mora-Janiszewska
ABCDEF 1, Kinga Bialic ABCDEF 1*, Anna Faryniak BF 1, Dorota Darmochwał-Kolarz BF 1
DOI: 10.12659/MSM.948897
Med Sci Monit 2025; 31:e948897
Table 1 Recent studies with comparisons between dominant taxonomies in group of women without and with GDM. In this table, recent studies are present in which the composition of gut microbiota is compared between normoglycemic women (control group) and women with gestational diabetes mellitus (GDM). The studies employed 16S rRNA sequencing or whole metagenome shotgun sequencing methods to identify and compare dominant taxonomic groups. The taxonomies are listed separately for each group (normoglycemic and GDM), with differences in microbial community structure and the potential relevance of these differences in GDM pathophysiology highlighted.
| Study | Number of woman surveyed GDM/control (total) | Gestational age (weeks) | Methods | Normoglycemic women | Women with GDM |
|---|---|---|---|---|---|
| Ye et al []84 | 36/16 (52) | 24–28 | 16s rRNA sequencing | Faecalibacterium spp. | |
| Cortez et al []85 | 26/42 (68) | 28–36 | 16s rRNA sequencing | Bacteroides spp. | |
| Crusell et al []80 | 50/157 (207) | 27–33 | 16S rRNA gene amplicon sequencing of the V1–V2 region | Anaerosporobacter, Marvinbryantia, Acetivibrio | |
| Su et al []86 | 21/32 (53) | 24–28 | 16s rRNA sequencing | Clostridiales, Clostridia, Proteobacteria, Actinobacteria | |
| Wei et al []87 | 15/18 (33) | 24–28 | 16s rRNA sequencing | Bacteroidetes, Bacteroidia, Bacteroidales | |
| Hu et al []88 | 201/201 (402) | 6–15 & 24–28 | 16s rRNA sequencing | Rothia, Actinomyces, Bifidobacterium, Adlercreutzia, Coriobacteriaceae, Lachnospiraceae spp. | Enterobacteriaceae, Ruminococcaceae spp., Veillonellaceae |
| Chen et al []89 | 30/28 (58) | 28 | 16s rRNA microarrary | Oscillospira, Bifidobacterium, Ruminococcaceae, Clostridiales, Gemmiger | Bacteroidetes spp., Dialister spp., Campylobacter spp., Enterococceae spp. |
| Ma et al []90 | 70/70 (140) | 10–14 & 42 days after delivery | 16s rRNA sequencing | Parasutterella, Parabacteroides, Megasphaera, Dialister, Ruminococcaceae Ruminococcaceae Ruminococcaceae Eubacterium xylanophilum group, Eubacterium eligens group | Eisenbergiella, Tyzzerella, Lachnospiraceae NK4A136 |
| Kuang et al []91 | 43/81 (124) | 21–29 | Whole metagenome shotgun sequencing | Ruminiclostridium, Roseburia, Eggerthella, Fusobacterium, Haemophilus, Mitsukella, Aggregatibacter | , , , , Citrobacter spp. |
| GDM – Gestational Diabetes Mellitus, 16S rRNA – 16S ribosomal RNA, rRNA – ribosomal RNA. | |||||