15 September 2025 : Clinical Research
Optimizing Ventilation Strategies to Reduce Pulmonary Complications in Frail Patients: A Comparative Study
Yang Cao AEG 1,2, Enci Liu CD 3, Yongling Xu AD 1, Changzheng Shangguan F 4, Mengxia Ge B 1, Changzheng Yuan AB 1, Baohui Xia A 1, Bo Zhang D 1, Di Gao B 1, Wangning Shangguan AE 2*, Juan Chen E 5DOI: 10.12659/MSM.948977
Med Sci Monit 2025; 31:e948977
Table 2 Comparison of intraoperative parameters.
| Variable | ΔP group (n=31)** | N group (n=30)** | t-value*** | P value |
|---|---|---|---|---|
| Pplat-T0 | 8±2 | 14±1 | −17.31 | <0.001 |
| Pplat-T1 | 15±2 | 14±1 | 1.50 | 0.138 |
| Pplat-T2 | 14±2 | 15±1 | −0.57 | 0.569 |
| Paw-T0 | 14±2 | 21±3 | −9.74 | <0.001 |
| Paw-T1 | 22±3 | 21±3 | 1.70 | 0.095 |
| Paw-T2 | 20±2 | 21±3 | −2.44 | 0.018 |
| Cdyn-T0 | 33.4±7.7 | 22.3±4.6 | 6.83 | <0.001 |
| Cdyn-T1 | 21.0±4.5 | 21.7±4.2 | −0.57 | 0.572 |
| Cdyn-T2 | 24.4±4.9 | 21.7±4.1 | 2.39 | 0.02 |
| P – plateau pressure; Paw – airway pressure; Cdyn – dynamic lung compliance; T0 – immediately after intubation; T1 – after 60 minutes of positive end-expiratory pressure titration; T2 –end of surgery. ** Values are presented as mean±SD. *** Paired Student’s t-test was used for comparisons within each group. **** | ||||