15 September 2025 : Clinical Research
Optimizing Ventilation Strategies to Reduce Pulmonary Complications in Frail Patients: A Comparative Study
Yang Cao AEG 1,2, Enci Liu CD 3, Yongling Xu AD 1, Changzheng Shangguan F 4, Mengxia Ge B 1, Changzheng Yuan AB 1, Baohui Xia A 1, Bo Zhang D 1, Di Gao B 1, Wangning Shangguan AE 2*, Juan Chen E 5DOI: 10.12659/MSM.948977
Med Sci Monit 2025; 31:e948977
Table 4 Repeated measurement indicators of PaO2, OI, and Cdyn at different time points.
| Variable | T0 | T1 | T2 | Repeated measures** | ||
|---|---|---|---|---|---|---|
| Mean±SD | Mean±SD | Mean±SD | F-value | P value | ||
| PaO | ΔP group | 177.0±35.2 | 172.0±36.1 | 168.0±37.0 | ||
| N group | 186.0±36.5 | 181.0±37.2 | 140.0±38.0 | |||
| Main effect of the group | 4.57 | 0.035 | ||||
| Main effect of time | 10.23 | 0.001 | ||||
| Interaction effect between group and time | 2.35 | 0.099 | ||||
| OI | ΔP group | 342.0±68.4 | 350.0±69.3 | 360.0±70.2 | ||
| N group | 372.0±70.4 | 362.0±71.2 | 280.0±68.0 | |||
| Main effect of the group | 3.46 | 0.068 | ||||
| Main effect of time | 9.88 | 0.001 | ||||
| Interaction effect between group and time | 1.23 | 0.299 | ||||
| Cdyn | ΔP group | 25.0±5.1 | 18.0±4.2 | 20.0±4.5 | ||
| N group | 33.1±5.2 | 25.3±4.3 | 23.9±4.6 | |||
| Main effect of the group | 5.68 | 0.02 | ||||
| Main effect of time | 8.90 | 0.002 | ||||
| Interaction effect between group and time | 1.99 | 0.135 | ||||
| PaO – partial pressure of arterial oxygen; OI – oxygenation index, calculated as PaO/FiO; Cdyn – dynamic lung compliance; T0 – immediately after intubation; T1 – after 60 minutes of PEEP titration; T2 = end of surgery. ** Repeated-measures ANOVA was used for the analysis. *** | ||||||