16 May 2025 : Clinical Research
Impact of Sitagliptin on Neprilysin and Glycemic Control in Newly Diagnosed Type 2 Diabetes Patients
Cuma Bulent Gül ABCDEF 1*, Aysegul Oruc CDF 1, Soner Cander ABF 1, Ensar Aydemir
BF 2, Ozen Oz Gül ABCDEFG 1
DOI: 10.12659/MSM.949107
Med Sci Monit 2025; 31:e949107
Table 3 Multivariable regression analysis of changes in neprilysin levels and study parameters.
| Dependent variable | Neprilysin change (β) | Neprilysin p-value | Age (β) | Age p-value | Gender (β) | Gender p-value | R-squared |
|---|---|---|---|---|---|---|---|
| BMI change | −0.312 | 0.028 | −0.037 | 0.11 | −0.017 | 0.964 | 0.206 |
| Waist circumference change | 0.661 | 0.361 | 0.048 | 0.688 | −3.426 | 0.087 | 0.118 |
| HOMA-IR change | 0.603 | 0.383 | −0.103 | 0.357 | −0.157 | 0.935 | 0.066 |
| The table presents the regression analysis showing the association between changes in neprilysin levels (log-transformed) and changes in body mass index (BMI), waist circumference, and homeostasis model assessment (HOMA). Neprilysin levels were log-transformed to stabilize variance and improve model fit. | |||||||