03 August 2025 : Database Analysis
Periodontal Implications of Porphyromonas gingivalis-Derived Metabolites in Host Antioxidant and Anti-Inflammatory Mechanisms: A Computational Analysis
Abdullah Alqarni
ABEF 1, Jagadish Hosmani ABEF 1, Saeed Abdulrahman Alassiri BCEF 1, Ali Fahad Abdullah Al Qahtani CDE 2, Mohammad Al Magbol EFG 2, Hussain Almubarak FG 1, Shankargouda Patil AEFG 3,4*
DOI: 10.12659/MSM.949167
Med Sci Monit 2025; 31:e949167
Table 1 Top 5 P. gingivalis metabolites that showed high affinity with PON1 protein.
| P. gingivalis metabolites | Docking score (kcal/mol) | Glide G score (kcal/mol) | Glide model |
|---|---|---|---|
| CHOP | −9.784 | −9.784 | −110.518 |
| CHOP | −8.346 | −8.45 | −86.049 |
| CHN | −8.203 | −8.207 | −85.193 |
| CHNOPS | −8.063 | −8.063 | −92.8 |
| CH2NOP | −8.002 | −8.002 | −91.426 |