Dexmedetomidine Dose-Dependent Modulation of Lung Function and AQP1 Expression During One-Lung Ventilation in Adults Undergoing Thoracoscopic Surgery

03 November 2025 : Clinical Research

YuanQiang Li^{ABCDEFG 1*}, BenJing Gong^{BFG 1}, SongLiu He^{BCG 1}

DOI: 10.12659/MSM.949221

Med Sci Monit 2025; 31:e949221

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Table 2 Comparison of Serum TNF-α concentration.

Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Mean difference (95% CI)P
Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Group C vs D1	Group C vs D2	Group D1 vs D2
Before DEX	1.31±0.14	1.26±0.12	1.33±0.11	0.216	–	–	–
OLV	1.58±0.13^a	1.48±0.12^a	1.44±0.12^a	0.003	0.10 (0.02, 0.18)^b	0.14 (0.06, 0.22)^b	0.04 (−0.04, 0.12)
					=0.015	=0.001	=0.307
OLV	1.79±0.11^a	1.67±0.11^a	1.63±0.13^a	<0.001	0.12 (0.05,0.19)^b	0.16 (0.08,0.24)^b	0.04 (−0.04,0.12)
					=0.001	<0.001	=0.300
OLV	1.92±0.14^a	1.84±0.11^a	1.72±0.12^a	<0.001	0.08 (0.00, 0.16)	0.20 (0.12, 0.28)^b	0.12 (0.05, 0.19)^c
					=0.051	<0.001	=0.002
ReTLV	2.03±0.11^a	1.96±0.12^a	1.85±0.13^a	<0.001	0.07 (−0.02, 0.16)	0.18 (0.09, 0.27)^b	0.11 (0.02, 0.20)^c
					=0.071	<0.001	=0.006
^a ^b ^c

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