Dexmedetomidine Dose-Dependent Modulation of Lung Function and AQP1 Expression During One-Lung Ventilation in Adults Undergoing Thoracoscopic Surgery

03 November 2025 : Clinical Research

YuanQiang Li^{ABCDEFG 1*}, BenJing Gong^{BFG 1}, SongLiu He^{BCG 1}

DOI: 10.12659/MSM.949221

Med Sci Monit 2025; 31:e949221

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Table 3 Comparison of Serum IL-8 concentration.

Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Mean difference (95% CI)P
Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Group C vs D1	Group C vs D2	Group D1 vs D2
Before DEX	0.65±0.03	0.64±0.03	0.66±0.02	0.123	–	–	–
OLV	0.81±0.02^a	0.75±0.03^a	0.73±0.03^a	<0.001	0.06 (0.04, 0.08)^b	0.08 (0.06, 0.10)^b	0.02 (0.00, 0.04)^c
					<0.001	<0.001	=0.004
OLV	0.89±0.03^a	0.84±0.02^a	0.81±0.03^a	<0.001	0.05 (0.03, 0.07)^b	0.08 (0.06, 0.10)^b	0.03 (0.01, 0.05)^c
					<0.001	<0.001	=0.001
OLV	0.95±0.03^a	0.93±0.04^a	0.88±0.03^a	<0.001	0.02 (−0.01, 0.05)	0.07 (0.04, 0.10)^b	0.05 (0.02, 0.08)^c
					=0.065	<0.001	<0.001
ReTLV	1.01±0.02^a	0.99±0.03^a	0.94±0.03^a	<0.001	0.02 (−0.00, 0.04)	0.07 (0.05, 0.09)^b	0.05 (0.03, 0.07)^c
					=0.024	<0.001	<0.001
^a ^b ^c

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