Dexmedetomidine Dose-Dependent Modulation of Lung Function and AQP1 Expression During One-Lung Ventilation in Adults Undergoing Thoracoscopic Surgery

03 November 2025 : Clinical Research

YuanQiang Li^{ABCDEFG 1*}, BenJing Gong^{BFG 1}, SongLiu He^{BCG 1}

DOI: 10.12659/MSM.949221

Med Sci Monit 2025; 31:e949221

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Table 4 Comparison of the immunohistochemical score of AQP1 in lung tissue.

Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Mean difference (95% CI)P
Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Group C vs D1	Group C vs D2	Group D1 vs D2
Pre-OLV	5.6±1.4	5.3±1.3	5.4±1.1	0.785	–	–	–
Post-resection	2.8±1.2^a	3.1±1.2^a	4.2±1.1^a	0.001	−0.30 (−1.19, 0.59)	−1.40 (−2.29, −0.51)^b	−1.10 (−1.99, −0.21)^c
					=0.239	<0.001	=0.002
t	6.664	5.444	3.347
	<0.001	<0.001	0.002
^a ^b ^c

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