Dexmedetomidine Dose-Dependent Modulation of Lung Function and AQP1 Expression During One-Lung Ventilation in Adults Undergoing Thoracoscopic Surgery

03 November 2025 : Clinical Research

YuanQiang Li^{ABCDEFG 1*}, BenJing Gong^{BFG 1}, SongLiu He^{BCG 1}

DOI: 10.12659/MSM.949221

Med Sci Monit 2025; 31:e949221

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Table 5 Comparison of intraoperative RI.

Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Mean difference (95% CI)P
Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Group C vs D1	Group C vs D2	Group D1 vs D2
Before DEX	0.47±0.02	0.46±0.04	0.48±0.02	0.139	–	–	–
OLV	1.76±0.12^a	1.49±0.12^a	1.45±0.14^a		0.27 (0.17, 0.37)^b	0.31 (0.21, 0.41)^b	0.04 (−0.06, 0.14)
				<0.001	<0.001	<0.001	=0.195
OLV	4.11±0.15^a	3.84±0.13^a	3.56±0.13^a		0.27 (0.16, 0.38)^b	0.55 (0.44, 0.66)^b	0.28 (0.17, 0.39)^c
				<0.001	<0.001	<0.001	<0.001
OLV	5.36±0.14^a	4.75±0.15^a	4.32±0.12^a		0.61 (0.50, 0.72)	1.04 (0.93, 1.15)^b	0.43 (0.32, 0.54)^c
				<0.001	<0.001	<0.001	<0.001
ReTLV	1.28±0.08^a	1.05±0.06^a	0.96±0.06^a		0.23 (0.18, 0.28)	0.32 (0.27, 0.37)^b	0.09 (0.04, 0.14)^c
				<0.001	<0.001	<0.001	<0.001
^a ^b ^c

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