Dexmedetomidine Dose-Dependent Modulation of Lung Function and AQP1 Expression During One-Lung Ventilation in Adults Undergoing Thoracoscopic Surgery

03 November 2025 : Clinical Research

YuanQiang Li^{ABCDEFG 1*}, BenJing Gong^{BFG 1}, SongLiu He^{BCG 1}

DOI: 10.12659/MSM.949221

Med Sci Monit 2025; 31:e949221

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Table 6 Comparison of intraoperative OI.

Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Mean difference (95% CI)P
Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Group C vs D1	Group C vs D2	Group D1 vs D2
Before DEX	458.3±20.1	462.3±23.2	451.4±22.3	0.289	–	–	–
OLV	298.5±21.2^a	310.2±21.1^a	345.3±23.4^a	<0.001	−11.7 (−28.3, 4.9)	−46.8 (−63.4, −30.2)^b	−35.1 (−51.7, −18.5)^c
					=0.096	<0.001	<0.001
OLV	259.3±23.4^a	262.6±22.6^a	294.4±22.3^a	<0.001	−3.3 (−20.5, 13.9)	−35.1 (−52.3, −17.9)^b	−31.8 (−49.0, −14.6)^c
					=0.294	<0.001	<0.001
OLV	218.2±22.4^a	227.2±21.3^a	256.1±23.3^a	<0.001	−9.0 (−25.9, 7.9)	−37.9 (−54.8, −21.0)^b	−28.9 (−45.8, −12.0)^c
					=0.208	<0.001	<0.001
ReTLV	315.4±24.3^a	335.4±23.3^a	359.5±21.4^a	<0.001	−20.0 (−37.3, −2.7)^b	−44.1 (−61.4, −26.8)^b	−24.1 (−41.4, −6.8)^c
					=0.007	<0.001	=0.001
^a ^b ^c

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