Dexmedetomidine Dose-Dependent Modulation of Lung Function and AQP1 Expression During One-Lung Ventilation in Adults Undergoing Thoracoscopic Surgery

03 November 2025 : Clinical Research

YuanQiang Li^{ABCDEFG 1*}, BenJing Gong^{BFG 1}, SongLiu He^{BCG 1}

DOI: 10.12659/MSM.949221

Med Sci Monit 2025; 31:e949221

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Table 7 Comparison of intraoperative Cdyn.

Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Mean difference (95% CI)P
Time interval	Group C (n=20)	Group D1 (n=20)	Group D2 (n=20)	P	Group C vs D1	Group C vs D2	Group D1 vs D2
Before DEX	44.3±8.2	46.2±6.1	43.4±6.4	0.430	–	–	–
OLV	31.2±6.2^a	33.3±5.1^a	34.2±5.1^a	0.221	–	–	–
OLV	23.4±5.4^a	26.2±5.6^a	31.4±6.5^a	<0.001	−2.8 (−7.4, 1.8)	−8.0 (−12.6, −3.5)^b	−5.2 (−9.8, −0.7)^c
					=0.116	<0.001	=0.005
OLV	19.3±3.2^a	23.4±3.5^a	27.1±5.4^a	<0.001	−4.1 (−6.3, −2.0)^b	−7.8 (−10.7, −4.9)^b	−3.7 (−6.6, −0.8)^c
					<0.001	<0.001	=0.0149
ReTLV	37.4±6.4^a	38.2±5.1^a	39.1±6.3	0.681	–	–	–
^a ^b ^c

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