19 August 2025 : Review article
Advances in Positron Emission Tomography/Computed Tomography for Diagnosing and Managing Primary Posterior Uveal Melanoma
Iwona Obuchowska
ABCDEF 1, Diana Anna Dmuchowska DE 1, Joanna Konopińska EF 1*
DOI: 10.12659/MSM.949252
Med Sci Monit 2025; 31:e949252
Introduction
Posterior Uveal Melanoma
Positron Emission Tomography
Role of PET/CT in the Detection of Posterior Uveal Melanoma
Role of PET/CT Imaging in Distinguishing Between Posterior Uveal Melanomas, Benign Lesions and Other Primary or Metastatic Intra-Ocular Malignancies
Role of PET/CT in Staging of Metastatic Uveal Melanoma
Monitoring of Treatment Outcomes in Posterior Uveal Melanoma with PET/CT
Limitations of PET/CT Imaging
Future Directions
Conclusions
References
Table 3 The AJCC* cancer staging system for posterior uveal melanoma (choroidal and ciliary body) in regard to regional lymph nodes involvement and distant metastasis.
| N criteria | |
|---|---|
| NX | Regional lymph nodes cannot be assessed |
| N0 | No regional lymph node involvement |
| N1 | Regional lymph node metastasis or discrete tumor deposits in the orbit |
| N1a | Metastasis in one or more regional lymph node(s) |
| N1b | No regional lymph nodes are positive, but there are discrete tumor deposits in the orbit that are not contiguous to the eye |
| M0 | No distant metastasis by clinical classification |
| M1 | Distant metastasis |
| M1a | Largest diameter of the largest metastasis ≤3.0 cm |
| M1b | Largest diameter of the largest metastasis 3.1–8.0 cm |
| M1c | Largest diameter of the largest metastasis ≥8.1 cm |
| * AJCC – American Joint Committee on Cancer. Source: . | |