Predictive Nomogram for Acute Kidney Injury Risk with Vancomycin and Piperacillin Tazobactam in Sepsis Treatment

04 July 2025 : Database Analysis

Guohua Liu^{ABCDEF 1}, Ji Li^{ABCFG 2}, Lin Chen^{DEFG 3}, Hao Ding^{ABCDFG 4*}, Sufang Yang^{ABCDEFG 1}

DOI: 10.12659/MSM.949340

Med Sci Monit 2025; 31:e949340

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Table 2 Multivariate regression model based on LASSO regression analysis results.

Variables	β	S.E	Z	P	OR (95% CI)
HT
No					1.00 (Reference)
Yes	0.30	0.26	1.19	0.236	1.35 (0.82~2.24)
Ventilation
No					1.00 (Reference)
Yes	1.43	0.39	3.70	<.001	4.19 (1.96~8.94)
Antihypertensive drugs
No					1.00 (Reference)
Yes	0.57	0.25	2.27	0.023	1.77 (1.08~2.91)
Vantotalval	0.10	0.05	2.02	0.043	1.11 (1.01~1.23)
BMI	0.06	0.02	2.41	0.016	1.06 (1.01~1.11)
Potassium	0.52	0.21	2.51	0.012	1.69 (1.12~2.54)
SOFA	0.11	0.04	2.55	0.011	1.12 (1.03~1.22)
HT – hypertension; SOFA – sequential organ failure assessment score; Vantotalval – total VAN dosage; Ventilation – mechanical ventilation; BMI – body mass index.

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