03 December 2025 : Clinical Research
Biologically Guided Gamma Knife Dose Painting for Recurrent High-Grade Gliomas: A Retrospective Study Using Functional MRI Techniques
Mehmet Hakan Seyithanoğlu
ABCDEFG 1*, İsmail Yurtsever ABCD 2, Meliha Gundag Papaker DEF 1, Ahmet Serdar Mutluer CDEF 3, Tolga Turan Dundar DEF 4,5, Serkan Kitis ABCEF 1, Kerime Akdur BEF 6, Alpaslan Mayadağlı AEF 6,7
DOI: 10.12659/MSM.949489
Med Sci Monit 2025; 31:e949489
Table 1 Patient-level dosimetry comparing uniform 16 Gy (plan 1) vs dose-painted 15–18 Gy (plan 2).Comparison of mean dose, integral dose, and volume of normal brain receiving ≥12 Gy (V12) between standard treatment (plan 1: uniform 16 Gy, simulated, not delivered) and dose-painting plans (plan 2: dose-painted 15–18 Gy; delivered).
| Sex | Plan 1 (16 Gy) | Plan 2 (15–18 Gy) | ||||
|---|---|---|---|---|---|---|
| Mean (Gy) | Integral dose (J) | V12 (cc) | Mean (Gy) | Integral dose (J) | V12 (cc) | |
| M | 2.2 | 5.8 | 71.4 | 2.1 | 5.8 | 70.25 |
| F | 2.7 | 8.9 | 116.58 | 2.6 | 8.6 | 110.61 |
| F | 2.9 | 8.9 | 126.03 | 2.8 | 8.7 | 124.57 |
| M | 2.1 | 7.9 | 85.35 | 2.1 | 7.9 | 85.41 |
| M | 3 | 9.9 | 163 | 3 | 9.8 | 162.97 |
| M | 3 | 9.9 | 134 | 3 | 10 | 136.4 |
| M | 1.5 | 5 | 550.9 | 1.5 | 4.9 | 55.04 |
| F | 2.4 | 8.4 | 104.13 | 2.4 | 8.5 | 105.46 |
| F | 1.4 | 4.6 | 14.92 | 1.3 | 4.3 | 13.92 |
| F | 1.5 | 4.7 | 58.55 | 1.5 | 4.7 | 57.36 |
| M | 2.5 | 7.5 | 130.39 | 2.5 | 7.4 | 130.11 |
| F | 0.9 | 2.9 | 24.26 | 0.8 | 2.8 | 23.92 |
| F | 1.2 | 3.4 | 32.11 | 1.1 | 3.3 | 32.09 |
| F | 1.5 | 4.7 | 60.33 | 1.4 | 4.6 | 60.28 |
| F | 3.1 | 9.3 | 91.47 | 2.9 | 8.7 | 91.32 |
| F | 1.1 | 2.5 | 14.87 | 1 | 2.4 | 14.48 |
| F | 2.2 | 7 | 91.39 | 2.1 | 7 | 91.3 |
| M | 2.4 | 8.2 | 93.28 | 2.3 | 8.1 | 93.15 |
| M | 3.8 | 13.9 | 239.75 | 3.7 | 13.7 | 238.25 |
| M | 1.3 | 5 | 45.71 | 1.2 | 5 | 45.68 |
| M | 3.6 | 12 | 250.21 | 3.5 | 11.9 | 250.18 |
| M | 1.9 | 6.1 | 63.28 | 1.8 | 6 | 63.2 |
| F | 3 | 9.4 | 126.49 | 3 | 9.2 | 126.38 |
| The mean dose – the average of the dose received by whole brain tissue; integral dose – average of the energy received by whole brain tissue; V12 dose – volume of brain tissues that received a dose of 12 Gy. F – female; M – male. | ||||||