03 December 2025 : Clinical Research
Biologically Guided Gamma Knife Dose Painting for Recurrent High-Grade Gliomas: A Retrospective Study Using Functional MRI Techniques
Mehmet Hakan Seyithanoğlu
ABCDEFG 1*, İsmail Yurtsever ABCD 2, Meliha Gundag Papaker DEF 1, Ahmet Serdar Mutluer CDEF 3, Tolga Turan Dundar DEF 4,5, Serkan Kitis ABCEF 1, Kerime Akdur BEF 6, Alpaslan Mayadağlı AEF 6,7
DOI: 10.12659/MSM.949489
Med Sci Monit 2025; 31:e949489
Table 4 Pearson correlation analysis revealing associations between baseline imaging biomarkers and post-treatment changes in volume transfer constant (ΔK-trans).
| Comparison | Pearson r | P value | Interpretation |
|---|---|---|---|
| Baseline K-trans vs ΔK-trans | −0.841 | 0.0012 | Strong inverse correlation (statistically significant) |
| Baseline Cho/NAA vs ΔK-trans | 0.091 | 0.791 | Very weak positive correlation (not statistically significant) |