Comparison of Substances in Combined Oral Contraceptives Used in Acne Vulgaris, Hirsutism, Migraine, and Dysmenorrhea

22 February 2026 : Review article

Patrycja Wójcikiewicz

^{ABCDEF 1*}, Gabriela Durlej

^{BCDEF 1}, Małgorzata Satora

^{BCDEF 1}, Rafał Tarkowski

^{AE 2}, Krzysztof Kułak

^{AEFG 2}

DOI: 10.12659/MSM.949520

Med Sci Monit 2026; 32:e949520

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Introduction Acne Vulgaris Hirsutism Migraine Dysmenorrhea Conclusions References

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Table 2 Summary of the studies describing the impact hormones implicit in different combined oral contraceptive pills on hirsutism.

Study	Year of study	Research group	Substance and a dose	Main findings
Sanam & Ziba et al []⁶	2011	91 women with hirsutism	150 mg DSG+30 mg EE versus150 mg LNG+30 mg EE	The decrement of hirsutism severity was significantly higher in the DSG+EE users
Moubasher et al []⁹	2020	20 women with hirsutism	LNG+EE or LNG alone	Serum free testosterone levels were non-significantly lower in a LNG+EE group compared to those taking LNG alone
DSG – desogestrel; EE – ethinylestradiol; COC – combined oral contraceptive; LNG – levonorgestrel; DRSP – drospirenone.

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