11 November 2025 : Clinical Research
Effect of Anesthesia on Functional Outcomes in Acute Ischemic Stroke Patients Undergoing Thrombectomy with the RECO Device
Yunlong Ding
ABEFG 1,2, Jiali Niu ACDE 3, Kai Dong BDE 4, Tingting Zhai BE 1, Yanrong Zhang BE 1, Wenjuan Wang BE 1, Hongjun Chen ADE 2,5, Yan Liu AEF 1*
DOI: 10.12659/MSM.949605
Med Sci Monit 2025; 31:e949605
Table 1 Comparison of demographic and baseline characteristics between the LA and GA Groups.
| Items | Before PSM | P | After PSM | P | ||
|---|---|---|---|---|---|---|
| LA (n=119) | GA (n=147) | LA (n=30) | GA (n=30) | |||
| Male | 71/119 (59.7) | 93/147 (63.3) | 0.548 | 14/30 (46.7) | 14/30 (46.7) | >0.999 |
| Age, y | 69 (59, 76) | 69 (58, 75) | 0.647 | 72 (61, 81) | 72 (60, 75) | 0.520 |
| Smoking | 0.245 | >0.999 | ||||
| Never | 84/99 (84.8) | 110/144 (76.4) | 23/30 (76.7) | 23/30 (76.7) | ||
| Current | 13/99 (13.1) | 31/144 (21.5) | 7/30 (23.3) | 6/30 (20.0) | ||
| Recent | 2/99 (2.0) | 3/144 (2.1) | 0 (0) | 1/30 (3.3) | ||
| Drinking status | 0.151 | >0.999 | ||||
| Never | 100/115 (87.0) | 115/144 (79.9) | 24/30 (80.0) | 24/30 (80.0) | ||
| Occasionally | 9/115 (7.8) | 13/144 (9.0) | 3/30 (10.0) | 3/30 (10.0) | ||
| Current | 4/115 (3.5) | 15/144 (10.4) | 3/30 (10.0) | 3/30 (10.0) | ||
| Recent | 2/115 (1.7) | 1/144 (0.7) | ||||
| Hypertension | 71/117 (60.7) | 103/144 (71.5) | 0.065 | 20/30 (66.7) | 20/30 (66.7) | >0.999 |
| Diabetes | 15/117 (12.8) | 22/143 (15.4) | 0.556 | 4/30 (13.3) | 5/30 (16.7) | >0.999 |
| Hyperlipidemia | 1/117 (0.9) | 1/144 (0.7) | >0.999 | 0 (0) | 0 (0) | |
| Previous stroke | 27/118 (22.9) | 30/144 (20.8) | 0.689 | 6/30 (20.0) | 8/30 (26.7) | 0.542 |
| Coronary heart disease | 18/118 (15.3) | 16/142 (11.3) | 0.342 | 4/30 (13.3) | 5/30 (16.7) | >0.999 |
| Atrial fibrillation | 41/119 (34.7) | 55/144 (38.2) | 0.564 | 12/30 (40.0) | 11/30 (36.7) | 0.791 |
| TIA | 2/118 (1.7) | 5/144 (3.5) | 0.615 | 1/30 (3.3) | 1/30 (3.3) | >0.999 |
| Cerebral hemorrhage | 1/118 (0.8) | 1/143 (0.7) | >0.999 | 0 (0) | 0 (0) | |
| Heart valve disease | 4/116 (3.4) | 8/144 (5.6) | 0.421 | 1/30 (3.3) | 0 (0) | >0.999 |
| TOAST classification | 0.722 | 0.606 | ||||
| Large atherosclerotic stroke | 26/62 (41.9) | 44/124 (35.5) | 15/30 (50.0) | 13/30 (43.3) | ||
| Cardiogenic cerebral embolism | 34/62 (54.8) | 75/124 (60.5) | 14/30 (46.7) | 17/30 (56.7) | ||
| Other stroke with definite aetiology | 1/62 (1.6) | 1/124 (0.8) | ||||
| Stroke of unknown aetiology | 1/62 (1.6) | 4/124 (3.2) | 1/30 (3.3) | 0 (0) | ||
| Inter-hospital transfer | 56/119 (47.1) | 21/147 (14.3) | <0.001 | 12/30 (40.0) | 10/30 (33.3) | 0.592 |
| PremRS | 0.576 | >0.999 | ||||
| 0 | 111/119 (93.3) | 136/147 (92.5) | 27/30 (90.0) | 28/30 (93.3) | ||
| 1 | 5/119 (4.2) | 6/147 (4.1) | 3/30 (10.0) | 2/30 (6.7) | ||
| 2 | 2/119 (1.7) | 5/147 (3.4) | ||||
| 4 | 1/119 (0.8) | 0 (0) | ||||
| Initial NIHSS | 18 (15, 24) | 16 (12, 22) | 0.040 | 20 (15, 25) | 21 (14, 27) | 0.947 |
| IVT | 16/119 (13.4) | 43/147 (29.3) | 0.002 | 3/30 (10.0) | 5/30 (16.7) | 0.704 |
| Onset-to-door time, min (n=118/145)* | 182 (99, 299) | 96 (54, 224) | <0.001 | 162 (69, 277) | 132 (71, 294) | 0.929 |
| Onset-to-puncture time, min (n=118/145)* | 319 (210, 431) | 205 (154, 331) | <0.001 | 279 (209, 346) | 240 (172, 351) | 0.294 |
| Onset-to-recanalization time, min (n=111/142)* | 374 (270, 515) | 300 (212, 421) | <0.001 | 367 (259, 453) | 316 (230, 452) | 0.446 |
| Puncture-to-recanalization time, min (n=111/143)* | 55 (41, 100) | 64 (46, 90) | 0.328 | 56 (39, 97) | 69 (45, 103) | 0.451 |
| Door-to-puncture time, min (n=118/145)* | 101 (69, 152) | 95 (76, 119) | 0.286 | 99 (69, 133) | 92 (69, 113) | 0.455 |
| Comparison of demographic and baseline characteristics between the LA and GA Groups. LA – local anesthesia; GA – general anesthesia; PSM – propensity score matching; TIA – transient ischemic attack; TOAST – trial of org 10172 in acute stroke treatment; mRS – modified Rankin scale; NIHSS – National Institutes of Health Stroke Scale; IVT – intravenous thrombolysis. * Before PSM, the reason for missing data primarily resulted from the inherent limitations of real-world registry data collection. The database relies on routine clinical documentation, where some variables were not systematically recorded for all patients during emergency care processes. After PSM, n=30/30. | ||||||