Eutopic Endometrium Immune Changes Involved in Development and Progression of Endometriosis: A Review

Izabela Dymanowska; Karolina Frankowska; Katarzyna Cencelewicz; Aleksandra Kusaj; Patrycja Bździuch; Piotr Stachurski; Grzegorz Polak

doi:10.12659/MSM.949643

08 January 2026 : Review article

Eutopic Endometrium Immune Changes Involved in Development and Progression of Endometriosis: A Review

Izabela Dymanowska^{ABCDEFG 1}, Karolina Frankowska

^{BCDEF 1*}, Katarzyna Cencelewicz

^{DEF 2}, Aleksandra Kusaj^{DEF 2}, Patrycja Bździuch^{DEF 2}, Piotr Stachurski

^{CDEF 3}, Grzegorz Polak

^{ABCDEFG 1}

DOI: 10.12659/MSM.949643

Med Sci Monit 2026; 32:e949643

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Introduction Abnormal Functioning of Eutopic Endometrium and the Progression of Endometriosis Immune Cells in the Eutopic Endometrium Immune Cell Interaction Network Cytokines Future Directions Conclusions References

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Table 1 Summary of the changes in Th17 cells expression in the eutopic endometrium in endometriosis.

Study	Studied material	Method of evaluation
Zhan et al 2025 []⁵⁰	Endometrial samples	Th17 gene sets evaluation
Miller et al 2022 []⁶⁴	Menstrual effluent	flow cytometry
Le et al 2021 []⁷⁰	Endometrial samples	RT-PCRIHC
Sisnett et al 2024 []⁷⁴	Endometrial samples	RT-qPCR
Chen et al 2012 []⁷⁵	Endometrial samples	RT-qPCRIHCWestern blot analysis
IHC – immunohistochemistry; IL – interleukin; HT – hormonal therapy.

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Eutopic Endometrium Immune Changes Involved in Development and Progression of Endometriosis: A Review

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