22 October 2025 : Review article
Non-Invasive Imaging in Post-Radiotherapy Monitoring of Non-Melanoma Skin Cancer
Piotr Sobolewski
ABCDEF 1, Mateusz Koper ABCDEF 1*, Irena Walecka ABCDEF 1
DOI: 10.12659/MSM.949669
Med Sci Monit 2025; 31:e949669
Table 1 Technical characteristics of reflectance confocal microscopy (RCM) and line-field confocal optical coherence tomography (LC-OCT).
| Parameter | Reflectance confocal microscopy | Line-field confocal optical coherence tomography | Ref. |
|---|---|---|---|
| Imaging depth | Typically 150–200 μm (max. approx. 300 μm); reaches epidermis + upper papillary dermis | Up to approx. 500 μm; reaches mid-papillary/superficial reticular dermis | [,]44 |
| Lateral resolution | 0.5–1 μm | Approx. 1 μm (isotropic) | [,]44 |
| Axial resolution | 3–5 μm | Approx. 1 μm (isotropic) | [,]44 |
| Imaging orientation | Horizontal en face optical sections parallel to skin surface | Primarily vertical cross-sectional (B-scan); device can also reconstruct horizontal en face slices | [,]59 |