Comparison of Outcomes From Intermittent Hemodialysis and Continuous Renal Replacement Therapy With Systemic or Regional Anticoagulation in 128 Patients in a Polish Intensive Care Unit

Joanna Wolska; Dariusz Onichimowski; Milena Samiec; Iwona Podlińska; Paweł Radkowski

doi:10.12659/MSM.949686

27 January 2026 : Database Analysis

Comparison of Outcomes From Intermittent Hemodialysis and Continuous Renal Replacement Therapy With Systemic or Regional Anticoagulation in 128 Patients in a Polish Intensive Care Unit

Joanna Wolska

^{ABCDEF 1,2*}, Dariusz Onichimowski

^{ACD 1,2}, Milena Samiec

^{E 1,3}, Iwona Podlińska

^{E 1,3}, Paweł Radkowski^{E 1,3}

DOI: 10.12659/MSM.949686

Med Sci Monit 2026; 32:e949686

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Table 4 Univariate analysis of odds ratios (OR) and 95% confidence intervals (CI) for in-hospital, 90-day, and long-term mortality according to patient characteristics.

	Long-term mortality (by 31/12/2020)			90-day mortality			In-hospital mortality
	OR (95% CI)		P	OR (95% CI)		P	OR (95% CI)		P
Therapy type
IHD	1.00	Reference		1.00	Reference		1.00	Reference
HEP	0.76	(0.19–3.05)	0.70	0.71	(0.24–2.13)	0.54	0.74	(0.27–2.04)	0.56
CITR	0.91	(0.23–3.64)	0.89	0.76	(0.26–2.23)	0.62	1.04	(0.38–2.88)	0.94
Age
<44	1.00	Reference		1.00	Reference		1.00	Reference
45–54	3.68	(0,87–15.53)	0.08	4.50	(1.15–17.65)	0.03	4.50	(1.15–17.65)	0.03
55–64	11.55	(2.06–64.72)	0.005	5.44	(1.49–19.87)	0.01	4.50	(1.27–15.90)	0.02
≥65	35.0	(3.87–316.7)	0.002	8.44	(2.35–30.28)	0.001	5.25	(1.59–17.32)	0.006
Sex
Women	1.00	Reference		1.00	Reference		1.00	Reference
Men	2.54	(0.81–7.98)	0.11	1.44	(0.56–3.74)	0.45	1.40	(0.56–3.47)	0.47
Hypertension
No	1.00	Reference		1.00	Reference		1.00	Reference
Yes	2.77	(0.59–13.02)	0.20	0.75	(0.30–1.87)	0.54	0.66	(0.28–1.56)	0.34
Diabetes mellitus
No	1.00	Reference		1.00	Reference		1.00	Reference
Yes	0.98	(0.20–4.79)	0.98	0.88	(0.26–2.92)	0.83	0.56	(0.19–1.64)	0.29
APACHE scale
I	1.00	Reference		1.00	Reference		1.00	Reference
II	2.13	(0.43–10.68)	0.36	2.22	(0.56–8.76)	0.25	2.36	(0.62–8.97)	0.21
III	4.06	(0.86–19.09)	0.08	3.99	(1.08–14.7)	0.04	5.08	(1.41–18.23)	0.01
Surgical
No	1.00	Reference		1.00	Reference		1.00	Reference
Yes	1.84	(0.59–5.72)	0.29	1.57	(0.64–3.87)	0.32	1.45	(0.61–3.43)	0.40
Pulmonary oedema
No	1.00	Reference		1.00	Reference		1.00	Reference
Yes	0.70	(0.20–2.43)	0.58	0.75	(0.28–2.00)	0.56	0.75	(0.29–1.92)	0.55
Acidosis
No	1.00	Reference		1.00	Reference		1.00	Reference
Yes	0.61	(0.20–1.86)	0.38	0.68	(0.29–1.61)	0.38	0.81	(0.36–1.85)	0.62
Fluid overload
No	1.00	Reference		1.00	Reference		1.00	Reference
Yes	0.36	(0.11–1.12)	0.08	0.39	(0.15–0.99)	0.047	0.42	(0.17–1.02)	0.05
Oliguria
No	1.00	Reference		1.00	Reference		1.00	Reference
Yes	2.12	(0.69–6.53)	0.19	1.62	(0.68–3.84)	0.28	1.65	(0.72–3.76)	0.23
Hyperkalemia
No	1.00	Reference		1.00	Reference		1.00	Reference
Yes	1.43	(0.37–5.47)	0.60	0.65	(0.26–1.63)	0.35	0.68	(0.28–1.66)	0.40
Liver failure
No	1.00	Reference		1.00	Reference		1.00	Reference
Yes	0.98	(0.20–4.79)	0.98	0.88	(0.26–2.92)	0.83	1.08	(0.33–3.58)	0.90
Time of initiating renal replacement therapy	0.98	(0.90–1.07)	0.67	0.95	(0.89–1.02)	0.13	0.96	(0.90–1.03)	0.25
ICU stay (length)	0.99	(0.98–1.01)	0.42	0.99	(0.97–1.00)	0.17	0.99	(0.97–1.00)	0.16
APACHE scale – Acute Physiology and Chronic Health Evaluation (APACHE) scale; APACHE II scale: I: 30; CI – confidence interval; CITR – patients subject to Continuous Renal Replacement Therapy with citrate anticoagulation; HEP – patients receiving continuous renal replacement therapy with heparin anticoagulation; ICU – intensive care unit; IHD – patients subject to intermittent hemodialysis; OR – odds ratio.

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Comparison of Outcomes From Intermittent Hemodialysis and Continuous Renal Replacement Therapy With Systemic or Regional Anticoagulation in 128 Patients in a Polish Intensive Care Unit

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