02 November 2025 : Clinical Research
Maternal Serum Galectin-1 in the First Trimester as a Potential Biomarker for Early Prediction of Pre-Eclampsia: A Prospective Study
Zhiling Yang BCE 1, Meilin Li AEFG 1, Caifeng Deng ABG 1, Chaolin Huang CDF 1*, Lingjiao Wu CDE 1DOI: 10.12659/MSM.949822
Med Sci Monit 2025; 31:e949822
Table 1 Baseline characteristics of the study population (n=2176).
| Characteristics | Pre-eclampsia (n=196) | Non-pre-eclampsia (n=1980) | p-value |
|---|---|---|---|
| Maternal age (years) | 26±4.75 | 23±3.85 | |
| Gestational age at enrollment (weeks) | 10.27±1.96 | 10.89±1.83 | 0.247 |
| Pre-pregnancy BMI (kg/m) | 27.31±4.37 | 24.28±3.24 | |
| SBP (mm/Hg) | 124.45±10.41 | 126.21±12.43 | 0.014 |
| DBP (mm/Hg) | 75.54±4.28 | 74.45±5.27 | 0.268 |
| TC (mmol/L) | 6.35±0.71 | 6.78±0.81 | 0.302 |
| TG (mmol/L) | 3.42±0.51 | 2.21±0.36 | |
| LDL-C (mmol/L) | 6.25±0.36 | 4.17±0.42 | |
| HDL-C (mmol/L) | 3.38±0.46 | 3.46±0.82 | 0.352 |
| AST (U/L) | 35±5.27 | 31±3.34 | 0.231 |
| ALT (U/L) | 27±3.52 | 28±3.217 | 0.176 |
| Creatinine (μmol/L) | 78±4.71 | 72±5.63 | 0.331 |
| Uric acid (μmol/L) | 336±21.43 | 347±19.72 | 0.427 |
| sFlt-1 (ng/ml) | 95±4.26 | 62±5.29 | |
| PlGF (ng/ml) | 21.57±4.17 | 35.81±5.25 | |
| Neonatal birth weight (g) | 3148±436 | 3642±641 | |
| Gestational age at delivery (weeks) | 36±2.34 | 38±1.21 | |
| Independent samples t-test was used for statistical analyses. A P | |||