Maternal Serum Galectin-1 in the First Trimester as a Potential Biomarker for Early Prediction of Pre-Eclampsia: A Prospective Study

02 November 2025 : Clinical Research

Zhiling Yang^{BCE 1}, Meilin Li^{AEFG 1}, Caifeng Deng^{ABG 1}, Chaolin Huang^{CDF 1*}, Lingjiao Wu^{CDE 1}

DOI: 10.12659/MSM.949822

Med Sci Monit 2025; 31:e949822

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Table 2 Relationship between serum galectin-1 levels and pre-eclampsia.

Galectin-1 levels (ng/ml)	Pre-eclampsia, n (%)	Adjusted OR	95% CI	p-value
T1: 12.23–22.51	95 (18.48)	4.45	3.34–6.67
T2: 22.68–33.31	65 (8.97)	2.83	1.04–4.27
T3: 33.34–45.47	36 (3.84)	1	Reference	–
Data were analyzed by logistic regression analysis after adjusting for maternal age, pre-pregnancy BMI, history of pre-eclampsia, and levels of TC, TG, HDL-C, LDL-C, sFlt-1, and PlGF. A p

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