02 November 2025 : Clinical Research
Maternal Serum Galectin-1 in the First Trimester as a Potential Biomarker for Early Prediction of Pre-Eclampsia: A Prospective Study
Zhiling Yang BCE 1, Meilin Li AEFG 1, Caifeng Deng ABG 1, Chaolin Huang CDF 1*, Lingjiao Wu CDE 1DOI: 10.12659/MSM.949822
Med Sci Monit 2025; 31:e949822
Table 3 Univariate and multivariate logistic regression analysis of potential risk factors for pre-eclampsia.
| Characteristics | Univariate analysis | p-value | Multivariate analysis | p-value |
|---|---|---|---|---|
| OR (95%CI) | 0R (95%CI) | |||
| TC (mmol/L) | 1.02 (0.85–1.34) | 0.254 | – | – |
| TG (mmol/L) | 0.87 (0.65–1.22) | 0.115 | – | – |
| LDL-C (mmol/L) | 1.13 (0.83–1.37) | 0.042 | – | – |
| Maternal age (years) | 3.42 (2.14–5.21) | 0.94 (0.72–1.52) | 0.217 | |
| Pre-pregnancy BMI | 3.37 (1.78–5.54) | 0.89 (0.62–2.21) | 0.145 | |
| SBP (mm/Hg) | 2.33 (1.21–4.36) | 1.14 (0.84–1.41) | 0.332 | |
| Galectin-1 (ng/ml) | 4.32 (1.42–6.57) | 4.35 (2.84–6.12) | ||
| PlGF (ng/ml) | 1.63 (1.34–1.97) | 1.53 (1.14–1.82) | ||
| sFlt-1 (ng/ml) | 3.12 (1.16–6.14) | 2.47 (1.03–5.27) | ||
| The multivariate analysis adjusted for potential confounders including maternal age, pre-pregnancy BMI, SBP, and levels of galectin-1, PlGF, sFlt-1, TC, TG, and LDL-C. CI – confidence interval; HR – hazard ratio. LDL-C – low-density lipoprotein cholesterol; TG – triglyceride; TC – total cholesterol; SBP – systolic blood pressure; PlGF – placental growth factor; sFlt-1 – soluble fms-like tyrosine kinase 1. A p | ||||