02 November 2025 : Clinical Research
Maternal Serum Galectin-1 in the First Trimester as a Potential Biomarker for Early Prediction of Pre-Eclampsia: A Prospective Study
Zhiling Yang BCE 1, Meilin Li AEFG 1, Caifeng Deng ABG 1, Chaolin Huang CDF 1*, Lingjiao Wu CDE 1DOI: 10.12659/MSM.949822
Med Sci Monit 2025; 31:e949822
Table 6 Correlations between galectin-1 levels and adverse pregnancy outcomes.
| Adverse pregnancy outcomes | Serum galectin-1 levels (ng/ml), OR (95% CI) | p-value | ||
|---|---|---|---|---|
| T1: 12.23–22.51 | T2: 22.68–33.31 | T3: 33.34–45.47 | ||
| Fetal growth restriction | 3.25 (1.67–5.32) | 1.82 (1.04–3.52) | 1.00 (reference) | |
| Cesarean section | 3.75 (1.14–5.25) | 2.14 (1.23–3.67) | 1.00 (reference) | |
| Small for gestational age | 4.36 (2.24–6.22) | 2.78 (1.21–4.32) | 1.00 (reference) | |
| Low birth weight | 4.27 (2.35–6.42) | 3.16 (1.32–4.81) | 1.00 (reference) | |
| Postpartum hemorrhage | 5.34 (2.71–7.23) | 3.24 (1.07–5.13) | 1.00 (reference) | |
| Preterm birth | 3.63 (1.15–5.63) | 2.21 (1.14–4.25) | 1.00 (reference) | |
| Low Apgar score | 4.27 (2.24–6.32) | 3.35 (1.24–5.42) | 1.00 (reference) | |
| Neonatal pneumonia | 0.91 (0.71–2.42) | 1.05 (0.72–1.28) | 1.00 (reference) | 0.221 |
| NICUA | 1.14 (1.02–1.42) | 1.18 (0.92–1.32) | 1.00 (reference) | 0.327 |
| NRDS | 0.92 (0.87–1.41) | 0.89 (0.71–1.38) | 1.00 (reference) | 0.143 |
| Data were analyzed by logistic regression analysis, and A p | ||||