06 October 2025 : Clinical Research
Changes in Hemogram-Derived Ratios in Patients with Sepsis Undergoing Cytokine-Filtered Continuous Renal Replacement Therapy in the Intensive Care Unit: A Retrospective Single-Center Study
Erkan Bayram ABCDEFG 1*, Müslüm Çiçek AEF 1, İlke Dolğun ABDF 2, İbrahim Akkoç ADE 3DOI: 10.12659/MSM.949964
Med Sci Monit 2025; 31:e949964
Table 2 Laboratory parameters over time in patients undergoing cytokine-filtered CRRTTemporal changes in CRP, WBC, PLR, and NLR from Day 0 to Day 3. Values are expressed as mean±standard deviation. Comparisons across days were evaluated by repeated measures analysis of variance or the Friedman test, as appropriate.
| Mean | Standard deviation | |
|---|---|---|
| CRP (Day 0) (mg/dL) | 17.7 | 11.4 |
| CRP (Day 1) (mg/dL) | 17.5 | 10.9 |
| CRP (Day 2) (mg/dL) | 19.0 | 10.1 |
| CRP (Day 3) (mg/dL) | 18.5 | 9.9 |
| WBC (Day 0) (10/μL) | 17.6 | 8.6 |
| WBC (Day 1) (10/μL) | 18.5 | 9.7 |
| WBC (Day 2) (10/μL) | 16.1 | 9.6 |
| WBC (Day 3) (10/μL) | 15.3 | 9.2 |
| PLR (Day 0) | 290.1 | 264.4 |
| PLR (Day 1) | 251.6 | 229.1 |
| PLR (Day 2) | 252.0 | 305.3 |
| PLR (Day 3) | 186.1 | 189.7 |
| NLR (Day 0) | 23.0 | 25.8 |
| NLR (Day 1) | 22.5 | 24.7 |
| NLR (Day 2) | 21.0 | 24.3 |
| NLR (Day 3) | 16.3 | 17.0 |
| CRP – C-reactive protein; WBC – white blood cell; PLR – platelet-to-lymphocyte ratio; NLR – neutrophil-to-lymphocyte ratio; CRRT – continuous renal replacement therapy. | ||