06 October 2025 : Clinical Research
Changes in Hemogram-Derived Ratios in Patients with Sepsis Undergoing Cytokine-Filtered Continuous Renal Replacement Therapy in the Intensive Care Unit: A Retrospective Single-Center Study
Erkan Bayram ABCDEFG 1*, Müslüm Çiçek AEF 1, İlke Dolğun ABDF 2, İbrahim Akkoç ADE 3DOI: 10.12659/MSM.949964
Med Sci Monit 2025; 31:e949964
Table 3 Pairwise changes in inflammatory markers over time in patients undergoing cytokine-filtered CRRTPairwise changes in CRP, WBC, PLR, and NLR across consecutive treatment days. Statistical comparisons were performed using repeated measures analysis of variance or paired t-tests. P-values <0.05 were considered significant (indicated by bold font).
| Parameters and comparisons | Mean change | Standard deviation | t-value | P-value |
|---|---|---|---|---|
| Change in CRP (Day 0 to Day 1) (mg/dL) | −0.0 | 3.6 | −0.0 | 1.0 |
| Change in CRP (Day 1 to Day 2) (mg/dL) | 0.9 | 7.4 | 1.17 | 0.2439 |
| Change in CRP (Day 2 to Day 3) (mg/dL) | 0.0 | 4.0 | 0.0 | 1.0 |
| Change in CRP (Day 0 to Day 3) (mg/dL) | −0.8 | 6.3 | −1.22 | 0.2239 |
| Change in WBC (Day 0 to Day 1) (10/μL) | 1.1 | 7.9 | 1.34 | 0.1826 |
| Change in WBC (Day 1 to Day 2) (10/μL) | −0.4 | 5.6 | −0.69 | 0.4927 |
| Change in WBC (Day 2 to Day 3) (10/μL) | 0.4 | 4.6 | 0.84 | 0.4039 |
| Change in WBC (Day 0 to Day 3) (10/μL) | −0.3 | 9.4 | −0.31 | 0.7589 |
| Change in PLR (Day 0 to Day 1) | −38.5 | 238.3 | −1.56 | 0.1227 |
| Change in PLR (Day 1 to Day 2) | 8.8 | 247.6 | 0.34 | 0.7326 |
| Change in PLR (Day 2 to Day 3) | −72.5 | 178.5 | −3.92 | |
| Change in PLR (Day 0 to Day 3) | −104.0 | 198.3 | −5.06 | |
| Change in NLR (Day 0 to Day 1) | −0.3 | 22.6 | −0.13 | 0.8984 |
| Change in NLR (Day 1 to Day 2) | 0.4 | 18.9 | 0.2 | 0.8387 |
| Change in NLR (Day 2 to Day 3) | −1.8 | 9.5 | −1.83 | 0.0709 |
| Change in NLR (Day 0 to Day 3) | −6.7 | 14.9 | −4.34 | |
| CRP – C-reactive protein; WBC – white blood cell; PLR – platelet-to-lymphocyte ratio; NLR – neutrophil-to-lymphocyte ratio; CRRT – continuous renal replacement therapy. | ||||