19 February 2026 : Clinical Research
Efficacy of Nano-Carbon Tracing Versus Indocyanine Green in Lymph Node Detection for Minimally Invasive Colorectal Resection
Pei Yang ABCDEF 1, Rui Bao ABCDEF 2, Yang He ABCDEF 1, Yongjiang Zhao CDE 3, Yao Wang CDE 4, Yongliang Yao ACDEF 3*DOI: 10.12659/MSM.949967
Med Sci Monit 2026; 32:e949967
Table 4 Comparison of postoperative quality-of-life scores (EORTC QLQ-C30) between the nano-carbon and control groups.
| Dimension | Time point | Nano-carbon labeling group (n=100) | Control group (n=100) | P-value | Mean difference (95% Confidence interval) | MCID note |
|---|---|---|---|---|---|---|
| Physical functioning | 6 months | 82.35±6.52 | 78.12±7.41 | 0.023 | +4.23 (0.6–7.8) | Borderline |
| Role functioning | 6 months | 79.45±7.23 | 74.20±8.11 | 0.041 | +5.25 (0.2–10.3) | Threshold met |
| Emotional functioning | 6 months | 80.60±7.05 | 76.30±8.29 | 0.057 | +4.30 (−0.1 to 8.7) | Not significant |
| Social functioning | 6 months | 78.50±6.67 | 73.40±7.88 | 0.036 | +5.10 (0.3–9.9) | Threshold met |
| Overall QoL | 6 months | 79.80±5.96 | 74.55±6.87 | 0.021 | +5.25 (1.0–9.5) | Threshold met |
| Fatigue | 6 months | 35.45±8.23 | 40.25±9.11 | 0.044 | −4.80 (−9.5 to −0.1) | Borderline |
| Pain | 6 months | 28.30±7.52 | 33.45±8.34 | 0.048 | −5.15 (−10.2 to −0.1) | Threshold met |
| Physical functioning | 1 year | 85.60±5.98 | 80.45±6.85 | 0.017 | +5.15 (1.0–9.2) | Threshold met |
| Role functioning | 1 year | 82.25±6.84 | 77.10±7.42 | 0.038 | +5.15 (0.3–10.0) | Threshold met |
| Emotional functioning | 1 year | 83.15±6.72 | 79.20±7.90 | 0.049 | +3.95 (0.0–7.9) | Borderline |
| Social functioning | 1 year | 81.75±6.15 | 76.25±7.53 | 0.032 | +5.50 (0.5–10.4) | Threshold met |
| Overall QoL | 1 year | 84.15±6.12 | 78.20±7.02 | 0.015 | +5.95 (1.2–10.7) | Threshold met |
| Fatigue ↓ | 1 year | 30.20±7.85 | 36.15±8.52 | 0.038 | −5.95 (−11.3 to −0.6) | Threshold met |
| Pain ↓ | 1 year | 25.60±6.85 | 29.75±7.90 | 0.041 | −4.15 (−8.2 to −0.1) | Borderline |
| * Scores transformed to 0–100 scale per EORTC manual. Higher functional or global scores indicate better QoL; higher symptom scores indicate worse symptoms. EORTC QLQ-C30 – European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30; MCID – minimum clinically important difference; QoL – quality of life. | ||||||