Histopathological Evaluation of the Pericardium in CABG Patients With and Without Prior SARS-CoV-2 Infection: A Prospective Observational Study

30 December 2025 : Clinical Research

Emrah Ereren

^{ACDFG 1*}, Hüseyin Ağırbaş

^{BEF 2}, İlker Hasan Karal

^{ABEG 1}, Seda Koç Şahin

^{ACE 3}, Fırat Tatlıdil

^{ABDF 4}

DOI: 10.12659/MSM.950106

Med Sci Monit 2025; 31:e950106

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Table 3 Comparison of histopathological findings between SARS-CoV-2 PCR-negative (n=70) and positive (n=23) patients.

Histopathological finding	Subgroup	SARS-CoV-2 PCR-negative n (%)	SARS-CoV-2 PCR-positive n (%)	χ2	P value
Macroscopic congestion	Fatty and dilated (FAD)	63 (90.0%)	19 (82.6%)	0.907	0.341
Macroscopic congestion	Fibrotic	7 (10.0%)	4 (17.4%)	0.907	0.341
Vascular proliferation	None	69 (98.6%)	23 (100%)	0.332	0.564
Vascular proliferation	Positive	1 (1.4%)	0 (0.0%)	0.332	0.564
Mesothelial hyperplasia	None	64 (91.4%)	19 (82.6%)	1.403	0.236
Mesothelial hyperplasia	Positive	6 (8.6%)	4 (17.4%)	1.403	0.236
Erythrocyte extravasation	None	27 (38.6%)	6 (26.1%)	1.179	0.278
Erythrocyte extravasation	Positive	43 (61.4%)	17 (73.9%)	1.179	0.278
Fibrin deposition	None	67 (95.7%)	23 (100%)	1.019	0.313

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