11 February 2026 : Clinical Research
Effect of Nutritional Status on Coagulation and Inflammation in Patients With Cirrhosis and Variceal Bleeding
Tian Yindi ABCD 1, Wang Mincong BCEF 2, Jia Hui BEF 2, Ma Le BDE 1, Luo Ni BCF 2, Guo Xiaoli BCF 2, Fu Hongxiao BEF 2, Luo Heng BEF 2, He Pu BF 2, Bao Xing BEF 2, Pan Shupei BCDE 2, Wang Baofeng ABEFG 2*DOI: 10.12659/MSM.950409
Med Sci Monit 2026; 32:e950409
Table 4 Correlation analysis between Controlling Nutritional Status (CONUT) score and coagulation and inflammatory indices. CONUT scores were positively correlated with coagulation indicators (PT, INR, APTT, and D-dimer) and inflammatory indicators (PCT, IL-6, and NLR).
| Screening tool | Variable | Spearman | P |
|---|---|---|---|
| Rs (95% CI) | |||
| PT | .508 (0.365, 0.626) | 0.000 | |
| INR | .515 (0.377, 0.631) | 0.000 | |
| PTA | −.432 (−0.567, −0.269) | 0.000 | |
| APTT | .388 (0.234, 0.512) | 0.000 | |
| CONUT | D-dimer | .370 (0.205, 0.520) | 0.000 |
| PCT | .174 (0.001, 0.340)6 | 0.048 | |
| IL-6 | .211 (0.040, 0.379)6 | 0.020 | |
| NLR | .275 (0.122, 0.420) | 0.001 | |
| Neutrophil count | .031 (−0.121, 0.175) | 0.706 | |
| PLT | −.286 (−0.426, −0.129) | 0.000 | |
| Lymphocyte count | −.405 (−0.526, −0.226) | 0.000 | |
| PT – prothrombin time; INR – international normalized ratio; PTA – prothrombin activity; APTT – activated partial thromboplastin time; PCT – procalcitonin; IL-6 – interleukin-6; NLR – neutrophil-to-lymphocyte ratio; PLT – platelet. | |||