Long-Term Outcomes of Anticoagulation Monotherapy Versus Combination Therapy in Atrial Fibrillation Patients with Complex Coronary Artery Disease

26 November 2025 : Database Analysis

Wei-Chieh Lee^{ABCDG 1,2*}, Wei-Ting Chang^{F 1,2}, Chon-Seng Hong^{B 2}, Chih-Hsien Lin^{B 2}, Chun-Yen Chiang

^{B 2}, Pei-Chieh Huang^{B 2}, Zhih-Cherng Chen^{BF 1,2}, Jhih-Yuan Shih^{B 1,2}, Hsiu-Yu Fang^{EF 3,4}

DOI: 10.12659/MSM.950655

Med Sci Monit 2025; 31:e950655

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Table 2 Clinical outcomes.

	Monotherapy Group (n=32)	Dual-therapy Group (n=24)	P value
	9 (28.1)	16 (66.7)	0.006
Massive GI bleeding (%)	1 (3.1)	3 (12.5)	0.303
Stroke (%)	5 (15.6)	2 (8.3)	0.686
Ischemic (%)	4 (12.5)	1 (4.1)	0.379
Hemorrhagic (%)	1 (3.1)	1 (4.1)	1.000
Re-vascularization (%)	4 (12.5)	12 (50.0)	0.003
	3 (9.4)	8 (33.3)	0.041
Target vessel (%)	3 (9.4)	9 (37.5)	0.019
Cardiovascular mortality (%)	1 (3.1)	1 (4.2)	1.000
All-cause mortality (%)	3 (9.4)	4 (16.7)	0.447
Data are expressed as mean±standard deviation or number (percentage). GI – gastrointestinal.

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